Cutaneous squamous cell carcinomas consistently show histologic evidence of in situ changes: A clinicopathologic correlation

Guenthner, Scott; Hurwitz, Robert; Buckel, Larry J.; Gray, Howard R.

doi:10.1016/s0190-9622(99)70119-2

Cited by 77 publications

(50 citation statements)

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“…One found that 24% of SCCs were contiguous with an AK, while another gave this ®gure as 94%. 4,5 The reliability of data from retrospective studies is questionable, and a prospective study was undertaken during the calendar year 1999 to determine how frequently SCCs arise in solar keratoses. In addition, it was intended to obtain more information about the clinical features of SCCs, in particular how thick they are at the time of presentation and what percentage is ulcerated.…”

mentioning

confidence: 99%

The Majority of Cutaneous Squamous Cell Carcinomas Arise in Actinic Keratoses

Czarnecki

Meehan

Bruce

et al. 2002

Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology

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confidence: 99%

The Majority of Cutaneous Squamous Cell Carcinomas Arise in Actinic Keratoses

Czarnecki

Meehan

Bruce

et al. 2002

Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology

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“…Although the exact rate of malignant transformation to SCC is unknown, the majority of SCCs appear to arise from within AKs [9]. Guenthner et al [10] examined 1,011 SCC specimens. In 983 lesions (97.2%), they found histopathological changes consistent with SCC in situ at the periphery or within the confines of the existing SCC[.]…”

Section: Discussionmentioning

confidence: 99%

Comparison of “Lesion-by-Lesion” and Field Photodynamic Therapy in the Prevention of Actinic Keratoses: A Randomized, Split-Face, Single-Blind Pilot Study

2016

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Background: Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local recurrence. Objective: The primary objective was to determine the number of new lesions at 9 months after methyl aminolevulinate photodynamic therapy (MAL-PDT). Secondary objectives were to determine the number of new lesions at 3 and 6 months after treatment and the percentage reduction of AKs from baseline at 3, 6, and 9 months after MAL-PDT. Methods: This was a single-centre, prospective, randomized, split-face, investigator-blinded pilot study with a study duration of 1 year. The study population comprised patients with AKs on the face or scalp, with a maximum of 10 AKs on each side. One side was treated with 1 session of “lesion-by-lesion” MAL-PDT (LT side) and the other side with 1 session of field MAL-PDT (FT side). Results: At 9 months the FT demonstrated significantly fewer new lesions. At every time point during the follow-up, we found a significant reduction in the number of AKs in the LT as well as in the FT sides. After 3 and 6 months we did not observe significant differences between the sides. However, after 9 months, the LT area showed significantly fewer remaining AKs, whereas the FT area demonstrated significantly fewer new lesions. Conclusions: Field treatment results in significantly fewer new AK lesions compared with lesion-by-lesion treatment.

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“…Klinische Studien zeigten, dass die spinozellulären Karzinome sich fast immer aus aktinischen Keratosen entwickeln und dass AK und Morbus Bowen spinozelluläre Karzinome in situ sind [10][11][12][13].…”

Section: äTiologie ((ü1))unclassified