Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients

Lindelöf, Bernt; Dal, Henrik; Wolk, Katarina; Malmborg, Niklas

doi:10.1001/archderm.141.4.447

Cited by 44 publications

(9 citation statements)

References 14 publications

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“…There are several studies that show a more lethal and more aggressive behavior of cSCCs in OTRs [ 7 , 21 ]. However, 69.4% of cSCCs in OTRs in this study were well differentiated, which is consistent with the results from Lindelöf et al showing an almost identical proportion of well-differentiated cSCCs (68.3%) [ 22 ]. In comparison with the non-OTRs, there was no significant difference in the degree of tumor differentiation.…”

Section: Discussionsupporting

confidence: 92%

Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

Stenman

Gonzalez

Gillstedt

et al. 2018

Dermatol Pract Concept

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BackgroundOrgan transplant recipients (OTRs) have a very high risk of developing cutaneous squamous cell carcinoma (cSCC). Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs.ObjectivesThe aim of this study was to investigate the degree of differentiation of cSCCs in OTRs compared with immunocompetent individuals.Patients/MethodsData from the Swedish Cancer Registry were crosschecked with data from the Transplant registry of the Transplant Institute at Sahlgrenska University Hospital in Gothenburg, Sweden. All OTRs with a diagnosis of cSCC, basosquamous carcinoma, and/or cSCC in situ established at the Department of Dermatology, Sahlgrenska University Hospital, during 2002–2015 were included. The control group consisted of non-OTRs with the same diagnoses during the same time period.ResultsDuring 2002–2015, 82 OTRs diagnosed with 515 tumors and 883 non-OTRs with 1,247 tumors were included. OTRs developed 0.47 tumors/year vs 0.10 tumors/year for non-OTRs, but no significant differences were observed in the degree of tumor differentiation of invasive cSCCs between OTRs and non-OTRs (P = 0.4). The distribution of poorly, moderately, and well-differentiated invasive cSCCs among OTRs and non-OTRs were 8.5% vs 12.5%, 22.1% vs 29.9%, and 69.4% vs 57.6%, respectively.ConclusionsOTRs do not develop a higher proportion of poorly differentiated cSCCs than non-OTRs.

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Section: Discussionsupporting

confidence: 92%

Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

Stenman

Gonzalez

Gillstedt

et al. 2018

Dermatol Pract Concept

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“…It was the older age group at transplantation in our population which significantly had higher rates of NMSC, reflecting a higher total life time sun exposure with increasing age. It is a fact that, for any individual, not only their extent of UV exposure after transplantation is of importance, but also their extent of exposure in the period prior to transplantation, and these, combined, are related to the mutagenic damage of the skin 32,33 . In our patients, older age at transplantation and the presence of precancerous conditions (AK) was significantly associated with the development of NMSC.…”

Section: Discussionmentioning

confidence: 68%

Non‐melanoma skin cancer and its risk factors in an Austrian population of heart transplant recipients receiving induction therapy

et al. 2008

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“…One hundred twenty‐three abstracts were excluded due to one or more of the following characteristics: a pediatric age group, fewer than 100 subjects; and review type article, case series, clinical trials, or studies of therapy or survival after diagnosis of a post‐transplant neoplasm. A total of 64 studies were reviewed in full text and analyzed in more detail (5, 7–69).…”

Section: Resultsmentioning

confidence: 99%

“…Only 12 of the 64 studies were based in large, national samples (5, 7, 13, 15, 17, 18, 21, 22, 28, 32, 36, 52). Although the national studies were more likely to report time at risk than were studies from transplant centers, half did not actually provide incidence rates.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic critique of literature on post‐transplant neoplasms in solid organ transplantation

Lanza

Wang

Simon

et al. 2009

Clinical Transplantation

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As survival of transplant recipients improves, long-term complications become more important. We reviewed epidemiologic literature on real-world risks of de novo neoplasia post-transplant. We searched the Medline/PubMed, Cochrane, and Embase databases for population-based studies on risk of neoplasia from 1998 to 2005. Selection criteria included: solid organ transplants, neoplastic outcomes, n > 500 subjects, age > or = 18 yr, and study design. Of 187 abstracts, 64 met criteria for study size, age range, topic, and design. We classified the articles by quality of reporting on components of cohort studies. Twelve of 64 studies reported cohort eligibility and exclusion criteria, defined time at risk, and ascertained incident neoplasms. Twenty-one studies reported prevalence of neoplasms for unspecified time periods, and only eight incidence studies reported person yr at risk. Three studies of all types of neoplasms in kidney recipients reported incidence ranging from 11.0 to 17.3 cases per 1000 person yr. Two studies of post-transplant lymphoproliferative disorders reported incidence of 0.4 to 2.5 cases per 1000 person yr in kidney recipients. More precise estimation of risks and rates, better description of study population, and more attention to confounding in comparisons of rates would make studies more meaningful. Reports should adhere to established guidelines for presenting methods and results in epidemiologic studies.

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Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients

Cited by 44 publications

References 14 publications

Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients

Non‐melanoma skin cancer and its risk factors in an Austrian population of heart transplant recipients receiving induction therapy

Epidemiologic critique of literature on post‐transplant neoplasms in solid organ transplantation

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