Cutaneous sporotrichosis: a six‐year review of 19 cases in a tertiary referral center in Malaysia

Tang, Min; Tang, Jyh Jong; Gill, Priya; Chang, Choong Chor; Baba, Roshidah

doi:10.1111/j.1365-4632.2011.05229.x

Cited by 49 publications

(56 citation statements)

References 31 publications

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“…In this study, 8/44 isolated strains exhibited the ability to grow at 37℃(thermotolerant) , which suggests that upon establishment of the infection in the human host, about one-fifth of the patients would contract the lymphocutaneous form instead of the fixed cutaneous disease. This is in contrast to another retrospective study that reported that all human cases of sporotrichosis in Malaysia attributable to cat bites or scratches were presented with the lymphocutaneous form 13) .…”

Section: Thermo-tolerance Of Clinical Isolates From Malaysiacontrasting

confidence: 99%

“…Since then, multiple reports of sporotrichosis in human patients have been published in Malaysia. Among these, a retrospective study reported 13/19 cases that were associated with preceding trauma, half of which were directly attributable to cat scratches or bites 13) . This highlights the role of cats not only as propagators but also as a significant risk factor for acquiring this disease in Malaysia, as similarly reported in other countries like Brazil and India 14−17) .…”

Section: Sporothrichosis In the Malaysian Veterinary Contextmentioning

confidence: 99%

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The Current Status of Feline Sporotrichosis in Malaysia

Han¹

2017

Medical Mycology Journal

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Feline sporotrichosis has been reported in Malaysia since the 1990ʼs. Since then, studies have revealed that clinical clade D, Sporothrix schenckii sensu stricto, of a single clonal strain is the most common cause of this disease in Malaysia. The prevalence of a single clonal strain from a clinical clade was never before reported in Asia in a specific geographical niche. This raises the possibility of a process of purifying selection and subsequent clonal proliferation. While agricultural practices may serve as the selective pressure, direct causality has yet to be established. Studies into the thermo-tolerability of the Malaysian clonal strain of S. schenckii sensu stricto revealed that a small minority of clinical isolates have the capacity to grow at 37℃, while the majority displayed low susceptibility to commonly used antifungals in clinical practice, such as itraconazole(ITZ)and terbinafine(TRB) . Despite unestablished breakpoints, suspected resistance(MIC > 4 mg/mL)towards amphotericin B(AMB)and fluconazole(FLC)was recorded in the isolates. This explains the often lack of clinical response in feline patients treated with recommended doses of antifungals, including ITZ. Coupled with the potential zoonotic transmission to clients and veterinarians, protracted treatment period, and subsequent cost of treatment, prognosis of feline sporotrichosis is often regarded to be poor. The use of a higher dose of ITZ has been reported, and an adoption of this high-dose treatment regime is reported in this manuscript, with complete cure achieved in cases of recalcitrant and/or unresponsive feline sporotrichosis, which would otherwise be euthanized.

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Section: Thermo-tolerance Of Clinical Isolates From Malaysiacontrasting

confidence: 99%

Section: Sporothrichosis In the Malaysian Veterinary Contextmentioning

confidence: 99%

The Current Status of Feline Sporotrichosis in Malaysia

Han¹

2017

Medical Mycology Journal

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“…Puede presentarse a cualquier edad, siendo más común en niños y adultos jóvenes, especialmente entre los 16 a 35 años (cuadro 1) (3,9,11). Sin embargo, hay una publicación del 2011 que reporta 15 casos de esporotricosis en niños menores de 10 meses de edad (12).…”

Section: Introductionunclassified

“…Sin embargo, hay una publicación del 2011 que reporta 15 casos de esporotricosis en niños menores de 10 meses de edad (12). Algunos estudios reportan una predominio en los hombres, lo cual podría corresponder a las actividades de campo que estos realizan; caso contrario se ha visto en la India y Japón, donde las mujeres son las más afectadas, probablemente por su participación activa en actividades al aire libre en estos países (3,9,11 La esporotricosis es la micosis subcutánea más frecuente, tiene una distribución mundial, siendo más común en áreas tropicales y subtropicales.…”

Section: Introductionunclassified

Esporotricosis y cromoblastomicosis: revisión de la literatura

Gaviria-Giraldo¹,

Cardona‐Castro²

2017

CES Med.

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ResumenLas micosis subcutáneas hacen referencia a infecciones producidas por hongos que se encuentran en la naturaleza, adquiridas por inoculación directa y limitadas a la dermis y tejido celular subcutáneo, pero pueden extenderse hacia la epidermis o hacia planos más profundos llegando a comprometer estructuras óseas, así como diseminarse y producir enfermedad sistémica. Dentro de las micosis subcutáneas más importantes en nuestro medio y de las cuales se hablarán en este artículo están la esporotricosis y la cromoblastomicosis; mientras que las menos frecuentes incluyen micetoma, quistes faeomicóticos, lacaziosis y la zigomicosis subcutánea.Palabras clave: Dermatomicosis, Esporotricosis, Cromoblastomicosis, Micosis subcutáneas. AbstractSubcutaneous mycoses, refer to infections caused by fungi which the ecologic niche is the nature, they are acquired by direct inoculation, limited to the dermis and subcutaneous tissue, but may extend into the epidermis or deeper levels reaching compromise bone structures and systemic spread and cause disease. Among the most important in our country, and which will discuss in this article, subcutaneous mycoses are sporotrichosis and chromoblastomycosis, mycetoma include less frequent, the faeomycosis, lacaziosis, and subcutaneous zygomycosis.Keywords: Dermatomycoses, Sporotrichosis, Chromoblastomycosis, Subcutaneous mycosis. IntroducciónLas infecciones micóticas incluyen un amplio grupo que van desde entidades superficiales hasta infecciones profundas asociadas a planos más profundos, que incluso llegan a comprometer estructuras óseas o diseminarse y producir enfermedad sistémica. Dentro de las micosis subcutáneas más importantes en nuestro medio están la esporotricosis y la cromoblastomicosis; las menos frecuentes son micetoma, quistes faeomicóticos, lacaziosis y zigomicosis subcutánea. Los microrganismos causantes se inoculan en la piel luego de un trauma con material vegetal contaminado con el hongo y por esto también han sido llamadas micosis de implantación (1,2).

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“…34 The unexpected histopathological findings in Case 1 were reviewed and corrected to conclude that SCC was not present.…”

Section: -28mentioning

confidence: 99%