Cutaneous Soft Tissue Tumors That Make You Say, “Oh $*&amp;%!”

Patel, Rajiv M.; Billings, Steven D.

doi:10.1097/pap.0b013e31826661d1

Cited by 11 publications

(6 citation statements)

References 69 publications

(69 reference statements)

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“…Histologically, most angiosarcomas show complex vessels lined by atypical endothelial cells with an inter-anastomosing pattern and inter-tumoral hemorrhage. In some angiosarcomas, vascular differentiation may be an extremely subtle nding in hematoxylin and eosin-stained sections and requires vascular immunohistochemical markers for recognition [11]. In our case, irregular vascular lumens and hemorrhages were observed within the tumor.…”

Section: Discussionmentioning

confidence: 54%

Metastatic maxillary gingival angiosarcoma with aggressive growth: A case report

Hoshimoto

Aoki

Ishii

et al. 2023

Preprint

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Angiosarcoma is a rare malignant tumor of endothelial origin. It is an aggressive neoplasm with early metastasis and poor prognosis and accounts for approximately 2% of all soft tissue sarcomas.Primary tumors arising in the oral cavity account for only 1% of all angiosarcomas. Here, we report a rare case of metastatic angiosarcoma of the gingiva originating from a primary mediastinal lesion. The patient was an 83-year-old man who presented with a maxillary interincisor tumor; it was a painless mass with rounded superficial necrosis measuring 23 mm × 17 mm on the labial side and 20 mm × 17 mm on the palatal side. The histopathological diagnosis was epithelioid angiosarcoma. Imaging revealed lesions in the mediastinum, lungs, liver, and skin. The primary lesion was considered a mediastinal lesion. As the tumor had spread throughout the body, palliative therapy was administered. However, the patient’s general condition deteriorated rapidly, and he died 3 weeks after the first visit. Diagnosis of oral metastatic malignancy may result in detection of malignant tumors at other sites. Therefore, it is important to detect and treat oral metastatic tumors early for long-term prognosis.

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Section: Discussionmentioning

confidence: 54%

Metastatic maxillary gingival angiosarcoma with aggressive growth: A case report

Hoshimoto

Aoki

Ishii

et al. 2023

Preprint

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“…Poorly differentiated cAS can be difficult to distinguish from other cutaneous carcinomas such as KS or melanoma. 25 Therefore, it is useful to assess a panel of endothelial markers such as von Willebrand factor, CD31, CD34, FLI1, and ERG since individual antibodies tend to be variably positive in different tumors. As for KS, CD31, and CD34 are the most frequently used immunohistochemical markers in supporting the diagnosis of cAS.…”

Section: Discussionmentioning

confidence: 99%

“…The usually ill‐defined lesions are characterized by irregular, anastomosing, and dilated vascular structures with pleomorphic endothelium that may be misinterpreted as hemangioma or lymphangioma, particularly in cases where only a superficial biopsy specimen is available. Poorly differentiated cAS can be difficult to distinguish from other cutaneous carcinomas such as KS or melanoma 25 . Therefore, it is useful to assess a panel of endothelial markers such as von Willebrand factor, CD31, CD34, FLI1, and ERG since individual antibodies tend to be variably positive in different tumors.…”

Section: Discussionmentioning

confidence: 99%

Aberrant cytoplasmic connexin43 expression as a helpful marker in vascular neoplasms

et al. 2021

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Background: Gap junctions consisting of connexins (Cx) are fundamental in controlling cell proliferation, differentiation, and cell death. Cx43 is the most broadly expressed Cx in humans and is attributed an important role in skin tumor development. Its role in cutaneous vascular neoplasms is yet unknown.Methods: Fifteen cases each of cutaneous angiosarcoma (cAS), Kaposi sarcoma (KS), and cherry hemangioma (CH) were assessed by immunohistochemistry for expression of Cx43. Expression pattern, intensity, and percentage of positively stained cells were analyzed. Solid basal cell carcinomas served as positive and healthy skin as negative controls.Results: Most cases of cAS presented with a strong Cx43 staining of almost all tumor cells, whereas endothelia of KS showed medium expression and CH showed mostly weak expression. In comparison with KS or cAS, the staining intensity of CH was significantly lower (P ≤ 0.001). All tissue sections of both cAS and KS were characterized by a mostly diffuse, cytoplasmic staining pattern of the vascular endothelia. None of those showed nuclear staining. Conclusion:The high-to-intermediate expression of Cx43 observed in all cases of cAS and KS suggests that this Cx may play a role in the development of malignant vascular neoplasms and serve as a helpful diagnostic marker.

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“…Although there is immunophenotypic overlap, absence of immunoreactivity for CD31, Fli-1, and SMARCB1 (INI-1) helps distinguish epithelioid sarcoma. 50 Absence or weak immunoreactivity for ERG in epithelioid sarcoma also can be helpful if antibody to C-terminus is used; epithelioid sarcomas are frequently ERG positive with antibodies against the N-terminus. 42,43 In predominantly spindled cases, leiomyosarcoma may be considered.…”

Section: Ko and Billingsmentioning

confidence: 98%