Cutaneous silent periods in multiple system atrophy

̌Sťetkářová, Ivana; Kofler, Markus; Majerová, Veronika

doi:10.5507/bp.2013.081

Cited by 12 publications

(4 citation statements)

References 44 publications

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“…The prolonged duration of CSP in patients with Parkinson’s disease was significantly lower after l -dopa treatment[ 21 ]. Patients with multiple system atrophy also show prolonged CSP duration[ 22 ]. In addition, Han et al found significantly longer CSP duration in patients with restless legs syndrome (RLS), which is considered a central sensitization syndrome[ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Lengthened Cutaneous Silent Period in Fibromyalgia Suggesting Central Sensitization as a Pathogenesis

et al. 2016

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The pathogenesis of fibromyalgia (FM) has not been clearly elucidated, but central sensitization, which plays an important role in the development of neuropathic pain, is considered to be the main mechanism. The cutaneous silent period (CSP), which is a spinal reflex mediated by A-delta cutaneous afferents, is useful for the evaluation of sensorimotor integration at the spinal and supraspinal levels. To understand the pathophysiology of FM, we compared CSP patterns between patients with FM and normal healthy subjects. Twenty-four patients with FM diagnosed in accordance with the 1990 American College of Rheumatology classification system and 24 age- and sex-matched healthy volunteers were recruited. The CSP was measured from the abductor pollicis brevis muscle. Demographic data, number of tender points, and visual analog scale and FM impact questionnaire scores were collected. The measured CSP and clinical parameters of the patient and control groups were compared. In addition, possible correlations between the CSP parameters and the other clinical characteristics were analyzed. Mean CSP latencies did not differ between patients (55.50 ± 10.97 ms) and healthy controls (60.23 ± 11.87 ms; p = 0.158), although the mean CSP duration was significantly longer in patients (73.75 ± 15.67 ms) than in controls (63.50 ± 14.05 ms; p = 0.021). CSP variables did not correlate with any clinical variables. The significantly longer CSP duration in FM patients suggests central dysregulation at the spinal and supraspinal levels, rather than peripheral small fiber dysfunction.

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Section: Discussionmentioning

confidence: 99%

Lengthened Cutaneous Silent Period in Fibromyalgia Suggesting Central Sensitization as a Pathogenesis

et al. 2016

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“…It was normalized after administration of low-dose propranolol in essential tremor 12 . Levodopa did not normalize any of the abnormal CSP parameters in patients with multiple system atrophy whereas; a single dose of levodopa may decrease the CSP duration in in patients with Parkinson's disease 13,14 .…”

Section: Discussionmentioning

confidence: 67%

Peripheral Silent Period In Cervical and Generalized Dystonia

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2021

Dicle Tıp Dergisi

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Objective: Dystonia is a movement disorder described by continuous or alternating muscle contractions causing unusual postures or insistent motions. Abnormal sensorimotor integration and abnormalities in inhibitory pathways are thought to have a role in pathogenesis. This paper aims to research the state of inhibitory pathways in the spinal cord in dystonia through documenting a silent period (SP) through cutaneous stimulation (CuSP) or mixed nerve stimulation (MnSP). Methods: 23 patients with dystonia were included in the study. Also, 19 healthy subjects were included in the study as a control group. Ages were similar between two groups. (p=0.092). CuSP and MnSP are recorded through abductor pollicis brevis and median nerve at the wrist respectively. Results: Onset latency, time, and suppression index of CuSP were equivalent between two groups. Moreover, the initiation and terminate latencies of MnSP, also duration, were similar between these two groups. I2 suppression index was lower in generalized dystonia patients compared to patients with cervical dystonia (100.0 vs 86.7±21.4%; F=4.252, 0.035). Conclusions: The most striking result to emerge from the data is that there was lower suppression during CuSP in generalized dystonia patients. Our results suggest that spinal inhibitory circuits are less active if only there is clinical involvement of the relevant segment.

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“…However, the results should be interpreted cautiously because of the low number of subjects in these studies. In contrast, others studies showed delayed and prolonged CuSP in MSA ( Stetkarova et al, 2015 ), probably due to defects in reticulospinal and corticospinal inputs that change spinal excitability ( Eusebio et al, 2007 ).…”

Section: Long Latency Reflex and Cutaneous Silent Periodmentioning

confidence: 88%