Cutaneous silent period changes in Type 2 diabetes mellitus patients with small fiber neuropathy

Önal, Münif; Ulaş, Ümit Hıdır; Öz, Oğuzhan; Bek, Semai; Yücel, Mehmet; Taşlıpınar, Abdullah; Odabaşı, Zeki

doi:10.1016/j.clinph.2009.12.024

Cited by 24 publications

(31 citation statements)

References 27 publications

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“…These authors concluded that the CSP may be a useful electrophysiological method for the detection and diagnosis of small fiber neuropathy in diabetic patients. Onal et al [29] also found similar findings. They found normal CSP in the upper extremity, but CSP of reduced duration and longer latency in the lower extremity.…”

Section: Discussionsupporting

confidence: 60%

Small Fiber Neuropathy Associated with Hyperlipidemia: Utility of Cutaneous Silent Periods and Autonomic Tests

Morkavuk

Leventoğlu

2014

ISRN Neurology

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Background. Established electrophysiological methods have limited clinical utility in the diagnosis of small fiber neuropathy. The cutaneous silent period (CSP) may be useful as a method for the evaluation of smaller and unmyelinated fiber dysfunctions. Hyperlipidemia is a very rare cause of small fiber neuropathy. In this study, hyperlipidemia and small fiber neuropathy in symptomatic patients with normal nerve conduction studies were evaluated with autonomic tests and cutaneous silent periods. Methods. Twenty-five patients with clinically suspected small fiber neuropathy and 23 healthy volunteers were included. CSP latency and duration, as well as CSP latency difference of the upper and lower extremities, were examined. Two tests were used to assess the autonomic nervous system, namely, the R-R interval variation test in basal and profound breath conditions and the sympathetic skin response. Results. Twenty-five patients with clinically suspected small fiber neuropathy and normal nerve conduction studies were compared with 23 controls. In the upper extremities, patients had prolonged CSP latencies (P = 0.034) and shortened CSP durations (P = 0.039), whereas in the lower extremities, patients had shortened CSP durations (P = 0.001). The expiration-to-inspiration ratios were also reduced in patients groups. There was no significant difference between sympathetic skin response latencies and amplitude of the case and control groups. Conclusion. Our findings indicate that CSP may become a useful technique for the assessment of small fiber neuropathy in hyperlipidemic patients.

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Section: Discussionsupporting

confidence: 60%

Small Fiber Neuropathy Associated with Hyperlipidemia: Utility of Cutaneous Silent Periods and Autonomic Tests

Morkavuk

Leventoğlu

2014

ISRN Neurology

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“…These parameters of the CSP can be useful as supplementary evaluation of the functional state of peripheral nerves and local spinal sensory motor networks in disease (Leis et al 2011;Onal et al 2010;Oz et al 2011;Svilpauskaite et al 2006).…”

Section: Introductionmentioning

confidence: 98%

Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle

2012

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The transient suppression of motor activity in the spinal cord after a cutaneous stimulus is termed the cutaneous silent period (CSP). It is not known if CSP is due to suppression of the premotor network or direct inhibition of motoneurons. This issue was examined by intracellular recordings from motoneurons in the isolated carapace-spinal cord preparation from adult turtles during rhythmic scratch-like reflex. Electrical stimulation of cutaneous nerves induced CSP-like suppression of motor nerve firing during rhythmic network activity. The stimulus that generated the CSP-like suppression of motor activity evokes a polysynaptic compound synaptic potential in motoneurons and suppressed their firing. This compound synaptic potential was hyperpolarizing near threshold for action potentials and was associated with a substantial increase in conductance during the CSP in the motor pool. These results show that direct postsynaptic inhibition of motoneurons contributes to the CSP.

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“…10,11 CSP is a transient suppression of electromyographic (EMG) activity that occurs during sustained muscle contraction and after electrical stimulation delivered to the fingers. [12][13][14][15][16][17][18] CSP is mediated mainly by Ad afferents. [13][14][15]17 The aim of this study was to investigate the possible neuropathic origin of the pain in PPS by examining clinical features and by assessing the function of both small and large fibers in order to detect a lesion of the somatosensory system.…”

mentioning

confidence: 99%

Neuropathic pain in post‐burn hypertrophic scars: A psychophysical and neurophysiological study

et al. 2012

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Cutaneous silent period changes in Type 2 diabetes mellitus patients with small fiber neuropathy

Cited by 24 publications

References 27 publications

Small Fiber Neuropathy Associated with Hyperlipidemia: Utility of Cutaneous Silent Periods and Autonomic Tests

Small Fiber Neuropathy Associated with Hyperlipidemia: Utility of Cutaneous Silent Periods and Autonomic Tests

Inhibition of motoneurons during the cutaneous silent period in the spinal cord of the turtle

Neuropathic pain in post‐burn hypertrophic scars: A psychophysical and neurophysiological study

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