Cutaneous Sarcoidosis Showing Multiple Papular Eruptions with Keratotic Plugs

Abstract

A 26-year-old woman developed 249 discrete papules on her lower extremities. Twenty-three of them had keratotic plugs. Histologic examination demonstrated granulomatous foci consisting of epithelioid cells and a epidermal invagination which was disrupted at the base and lateral sites. This invagination was considered to represent transepithelial elimination.

Cutaneous sarcoidosis with aggregated comedones in a young woman possibly associated with cosmetic laser treatment

“…There have been few cases of cutaneous sarcoidosis showing keratotic plugs. 2,3 All of those cases showed solitary keratotic papules, and no plaque with aggregated comedones as in the present case has been reported. As a pathomechanism of plug formation, Higari et al 2 reported transepithelial elimination, which was not observed in our case.…”

“…2,3 All of those cases showed solitary keratotic papules, and no plaque with aggregated comedones as in the present case has been reported. As a pathomechanism of plug formation, Higari et al 2 reported transepithelial elimination, which was not observed in our case. It is possible that the plugs formed as a result of follicular obstruction as in comedones induced by widespread sarcoidal granulomas.…”

Transepithelial elimination in sarcoidosis: a frequent finding

“…Sarcoidosis with histopathologic evidence of transepithelial elimination was previously considered a rare phenomenon, with six cases described in the English literature . Additionally, three cases have been described in the foreign literature, but are not detailed in this article .…”

“…Cutaneous sarcoidosis with histopathologic evidence of transepithelial elimination was previously considered a rare phenomenon, with six cases described in the English literature to date . We begin by describing a case of cutaneous sarcoidosis with histopathologic evidence of transepithelial elimination and also complete a review of the English literature regarding this phenomenon.…”