Cutaneous sarcoidosis in Caucasians

Veien, Niels K.; Stahl, Dorrit; Brodthagen, H

doi:10.1016/s0190-9622(87)70070-x

Cited by 120 publications

(109 citation statements)

References 16 publications

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“…In contrast, nail changes are more unusual, ranging from 1 in 400 to 3 in 188 cases, and they are often associated with chronic systemic disease [1,2,4,5]. …”

Section: Discussionmentioning

confidence: 99%

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Noriega

Criado

Gabbi

et al. 2015

Skin Appendage Disord

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The most commonly seen nail change in sarcoidosis, often associated with chronic systemic disease, is onychodystrophy. Imaging of hands, feet and chest is of paramount importance when nail sarcoidosis is suspected, for evaluation of bone cysts and pulmonary involvement, respectively. We report 2 cases of sarcoidosis that developed nail involvement - one with pulmonary disease, and the other without any evidence of systemic involvement, which is very rare.

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“…In contrast, nail changes are more unusual, ranging from 1 in 400 to 3 in 188 cases, and they are often associated with chronic systemic disease [1,2,4,5]. …”

Section: Discussionmentioning

confidence: 99%

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Noriega

Criado

Gabbi

et al. 2015

Skin Appendage Disord

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“…Ulcerative sarcoidosis, as seen in our patient, is rare, occurring in 1.1% of Caucasian patients [11]. In a review of 35 well-documented cases in the English-language literature, Albertini et al [5]found a female predominance with a male-to-female rate of 1:2.…”

Section: Discussionmentioning

confidence: 55%

Ulcerative Sarcoidosis Successfully Treated with Apligraf

2001

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The case of a 73-year-old female patient is reported with a 25-year-long history of widespread cutaneous sarcoidosis without any known extracutaneous manifestations. The skin manifestations started with erythematous and plaque-like lesions that had ulcerated on the legs for the last half-year. A relevant venous insufficiency or other etiology of the ulcers could not be found. Histology from lesions of the trunk and from the surroundings of the ulcers revealed the typical noncaseating granulomas. A systemic involvement could not be observed; leukopenia and a slightly elevated angiotensin-converting enzyme level in the serum were found. Topical steroids did not prove successful on the ulcers. Apligraf, a bilayered skin equivalent, was transplanted twice on the ulcers leading to complete closure within 3 months. A therapy with systemic steroids could thus be avoided.

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“…Less common are ulcerative lesions, generalized erythroderma, ichthyosiform sarcoidosis, and scarring alopecia.1"3 In a study of cutaneous sarcoidosis in blacks, flesh-colored papules were the most frequent specific lesions, and hypopigmented mac¬ ules were also common; black patients often have psoriasiform sarcoidal plaques.1 In the past, scar sarcoidosis had been con¬ sidered a more unusual specific cutaneous lesion,3 although a recent study found sarcoidal infiltration of scarification marks to be the most common cutaneous manifestation of sarcoido¬ sis in patients in Nigeria.4 Another, more recent study of cu¬ taneous sarcoidosis in whites found that lupus pernio, scar in¬ filtrates, and plaques were the most common clinical lesions, while papules were fairly uncommon. 5 Scar infiltrates may appear early in the disease, before pul¬ monary parenchymal changes, and may be associated with hi¬ lar adenopathy or erythema nodosum. Most patients with scar sarcoidosis have other systemic manifestations, and changing scars in patients in remission may indicate disease exacerba¬ tion.3 However, James6 coined the term "local sarcoid-tissue reaction" to describe patients with sarcoid tissue limited to the skin without other systemic changes.6 Hanno et al7 also described patients with purely cutaneous sarcoidosis and oth¬ ers who also had evidence of sarcoidosis in other organ systems but were asymptomatic and required no therapy.…”

Section: Discussionmentioning

confidence: 99%

Reappearance of Quiescent Scars

Manz

Rodman²

1993

Arch Dermatol

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A 59-year-old black man with borderline hypertension and gout presented with the complaint that quiescent faded scars on his face, trunk, and extremities obtained from minor childhood injuries had suddenly become prominent and erythematous. He had been taking dyazide and allopurinol for several years. His family had no history of any skin diseases.Physical examination revealed firm, erythematous, nodular, minimally tender papules and plaques at sites of previous trauma (Fig 1).The biopsy specimen obtained from a lesion on his right thigh demonstrated multiple, well-demarcated, large, non\x=req-\ caseating, epithelioid granulomas with histiocytes and multinucleated giant cells (Fig 2). Special stains for aci d\x=req-\ fast bacilli and fungi were negative as was polarization for foreign bodies.Additional laboratory investigations included complete blood cell count and sequential multiple analyzer, which showed normal results, and a chest roentgenogram (Fig 3).

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Cutaneous sarcoidosis in Caucasians

Cited by 120 publications

References 16 publications

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Nail Sarcoidosis with and without Systemic Involvement: Report of Two Cases

Ulcerative Sarcoidosis Successfully Treated with Apligraf

Reappearance of Quiescent Scars

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