Cutaneous rhabdomyoma in an 82-year-old White man

Casale, Jarett; Uddin, Sharif; Upchurch, Britton; Arida, Muammar; Ingraffea, Adam

doi:10.5070/d329361429

Cited by 1 publication

(1 citation statement)

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“…The non‐polarizable crystalline inclusions usually appear needle‐like or rhomboid in shape and are arranged in parallel arrays. The histopathologic differential diagnosis of CSH can include many entities and are summarized in Table 2 16,17 …”

Section: Discussionmentioning

confidence: 99%

Cutaneous crystal storing histiocytosis: A case series with review of literature

Homsi,

Knapp,

Agrawal

et al. 2024

J Cutan Pathol

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Crystal‐storing histiocytosis (CSH) is a rare condition in which crystals accumulate in the cytoplasm of histiocytes and is usually associated with a lymphoplasmacytic neoplasm. Cutaneous CSH is extraordinarily rare and limited to case reports in the literature. We report two cases of this disease with cutaneous involvement. Case 1 was a 65‐year‐old male with a 4‐month history of a pruritic eruption that started as a solitary pink to skin‐colored indurated plaque on the anterior neck before progressing to involve the whole neck, chest wall, and face. Case 2 was a 54‐year‐old woman with a history of unspecified “lymphoma” who presented with a soft nodule on the forearm. Biopsies from both cases had similar findings and showed a proliferation of epithelioid cells with pink cytoplasm and intracellular crystalline structures infiltrating the dermis and subcutaneous fat. In the first case, the cells were positive for CD43, CD45, CD68, and IgG kappa, and in the second case, the crystals were positive for IgG lambda. Based on these findings, the patients were diagnosed with cutaneous CSH. We highlight this rare diagnosis and the importance of investigating an underlying lymphoplasmacytic neoplasm.

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Section: Discussionmentioning

confidence: 99%