Cutaneous Recall Phenomenon with Vinorelbine

Abstract

PublishedOnline, 23 Aug 20II, theannals .com 001 1O.I345/aph.IQ279 Comment: Economic Impact of Therapeutic Substitution of a Brand Selective Serotonin Reuptake Inhibitor with an Alternative Generic Selective Serotonin Reuptake Inhibitor in Patients with Major Depressive Disorder TOTHE EDITOR: In light of differences in safety,efficacy,and cost-effectiveness profiles of different selective serotonin reuptake inhibitors (5S-Rls), controversy surrounds therapeutic substitution of a branded drug theannals.com

Pyoderma gangrenosum arising on vinorelbine infusion site with additional histopathological features of syringosquamous metaplasia

“…Vinorelbine is a semisynthetic vinca alkaloid that interferes with microtubule assembly. Cutaneous side effects related to vinorelbine chemotherapy include erythema at the injection site, skin necrosis as a result of extravasation of the agent, erythrodysesthesia, morbilliform drug eruption, serpentine supravenous hyperpigmentation, radiation recall dermatitis, and leukocytoclastic vasculitis [9][10][11][12][13][14]. Up to 28 % of patients receiving vinorelbine are reported to have injection site reactions, but we could find no previous reports of PG arising at a vinorelbine infusion site [9].…”

“…Cutaneous side effects related to vinorelbine chemotherapy include erythema at the injection site, skin necrosis as a result of extravasation of the agent, erythrodysesthesia, morbilliform drug eruption, serpentine supravenous hyperpigmentation, radiation recall dermatitis, and leukocytoclastic vasculitis [9][10][11][12][13][14]. Cutaneous side effects related to vinorelbine chemotherapy include erythema at the injection site, skin necrosis as a result of extravasation of the agent, erythrodysesthesia, morbilliform drug eruption, serpentine supravenous hyperpigmentation, radiation recall dermatitis, and leukocytoclastic vasculitis [9][10][11][12][13][14].…”

Entwicklung eines Pyoderma gangraenosum an der Infusionsstelle von Vinorelbin mit zusätzlichen histopathologischen Merkmalen einer syringo‐squamösen Metaplasie

“…Zu den kutanen Nebenwirkungen einer Chemotherapie mit Vinorelbin zählen unter anderem Erytheme an der Injektionsstelle, Hautnekrosen als Resultat einer Extravasation des Wirkstoffs, Erythrodysästhesie, morbilliforme Arzneimittelexantheme, eine serpentinenförmige, der darunterliegenden Vene folgende Hyperpigmentation, Recall-Radiodermatitis und leukozytoklastische Vaskulitis [9][10][11][12][13][14]. Zu den kutanen Nebenwirkungen einer Chemotherapie mit Vinorelbin zählen unter anderem Erytheme an der Injektionsstelle, Hautnekrosen als Resultat einer Extravasation des Wirkstoffs, Erythrodysästhesie, morbilliforme Arzneimittelexantheme, eine serpentinenförmige, der darunterliegenden Vene folgende Hyperpigmentation, Recall-Radiodermatitis und leukozytoklastische Vaskulitis [9][10][11][12][13][14].…”