Cutaneous Reactions to Drugs Used for Rheumatologic Disorders

Roth, Donna E.; Spencer, Linda V.; Ahrens, Edwin M.

doi:10.1016/s0025-7125(16)30634-4

Cited by 13 publications

(2 citation statements)

References 80 publications

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“…18,19 DF may also cause cutaneous reactions as well as allergic contact dermatitis. 20,21 DF is, furthermore, one of the most common environmental pharmaceutical contaminants; it has been found in many sewage-treatment plant effluents, rivers and lake water. 22 DF can be applied as gel or as liposome system for dermal applications, and thus personal hygiene leads to considerable concentrations in wastewater.…”

Section: Introductionmentioning

confidence: 99%

Photodegradation mechanism of the common non-steroid anti-inflammatory drug diclofenac and its carbazole photoproduct

Musa

Eriksson

2009

Phys. Chem. Chem. Phys.

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Diclofenac (DF) is a widely used non-steroid anti-inflammatory drug, associated with a range of side effects. The phototoxicity of DF is studied herein employing computational quantum chemistry at the B3LYP/6-31G(d,p) level of theory. The results show that the drug readily absorbs radiation from the UV-region. The deprotonated form spontaneously dechlorinates from its triplet state leading to ring closure and formation of an active photoproduct: chlorocarbazole acetic acid, CCA. The formed CCA is also photodegraded easily from its deprotonated triplet state. Photodegradation routes of deprotonated CCA are decarboxylation (barrier less than 4.5 kcal mol(-1)) and dechlorination (barrier around 6.2 kcal mol(-1)). The energy barrier required for dechlorination to take place from the neutral from is about 20 kcal mol(-1). The differences between the molecular orbitals of the neutral and the deprotonated forms of DF and CCA and spectra obtained using time-dependent density-functional theory (TD-DFT), in addition to the different radical and oxygenated intermediate species formed during the photodegradation mechanism, are discussed in more detail. The theoretical results obtained herein are in line with the experimental results available to date.

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Section: Introductionmentioning

confidence: 99%

Photodegradation mechanism of the common non-steroid anti-inflammatory drug diclofenac and its carbazole photoproduct

Musa

Eriksson

2009

Phys. Chem. Chem. Phys.

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“…There are some reports of drug eruptions such as contact dermatitis [10], cutaneous vasculitis [11], generalized bullous fixed drug eruption [12], toxic epidermal necrolysis, exfoliative dermatitis [13] and lichenoid eruption [14] related to the use of flurbiprofen. A rare case of myocarditis due to a hypersensitivity reaction caused by oral flurbiprofen has also been described [15].…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis to Over-the-Counter Flurbiprofen in a Child

et al. 2016

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Non-steroidal anti-inflammatory drugs are suspected to cause drug hypersensitivity very frequently in paediatric patients. In this article, we describe the first case of anaphylaxis to flurbiprofen in a child and provide insight into the possibility of severe reactions and even anaphylaxis to over-the-counter flurbiprofen. Finally, the importance of a rigorous allergy work-up in reaching a confident diagnosis and providing the patient with a safe alternative is shown.

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