“…Although no prospective studies have been performed, this complication appears to be extremely rare, since only a limited number of cases of UFH-induced skin necrosis and seven cases (including our case) after LMWH have been reported. In addition, a number of cases of erythematous skin reactions after administration of UFH [9,10,21,23,24] and LMWH [9,10,13,18,21] have been described. In the seven cases of LMWH skin necrosis (Table 1) the lesion developed after about 1 week of treatment, starting with painful erythema and progressing within a short time to necrosis.…”