Cutaneous reaction to inhaled treprostinil

Regio- and Stereocontrolled Dieckmann Approach to Treprostinil-Inspired, Polycyclic Scaffold For Building Macrocyclic Diversity

“…Treprostinil (UT-15, Figure , 1 ) is a synthetic drug with a proven track record for the treatment of pulmonary hypertension, a fatal lung disease. − The design and synthesis of this drug was achieved, initially by starting with prostacyclin (PGI 2 , 2 ), which is a key physiological prostanoid. , Prostacyclin (PGI 2 ) is one of the major metabolic products from arachidonic acid during the vasculature process and is normally produced in endothelium and smooth muscles. − PGI 2 is a highly potent endogenous vasodilator in both systemic and pulmonary circulation and is also known to inhibit the platelet aggregation and adhesion. ,− Because of the limitations associated with PGI 2 (i.e., short half-life etc. ), the synthesis efforts for obtaining a better compound eventually led to reaching a successful drug, treprostinil!…”