Cutaneous Pseudolymphomas

Romero‐Pérez, David; Martínez, M.; Encabo-Durán, Belén

doi:10.1016/j.adengl.2016.07.011

Cited by 13 publications

(28 citation statements)

References 114 publications

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“…Treatment consists mainly of the avoidance of causative allergens. The allergens implicated include phosphorus, N‐isopropyl‐N‐phenyl‐4‐phenylenediamine, ethylenediamine, dihydrochloride, cobalt naphthenate, nickel sulfate, paraphenylenediamine, gold sodium thiosulfate, zinc, squaric acid dibutylester, and methylchloroisothiazolinone (Romero‐Perez, Blanes, & Encabo‐Duran, ). Treatments include local and intralesional corticosteroids and tacrolimus ointments.…”

Section: Discussionmentioning

confidence: 99%

Lymphoma or pseudolymphoma: A report of six cases and review of the literature

Zhu

Zhang

Wang

et al. 2019

Dermatologic Therapy

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To explore and compare the clinical presentations and pathologic features of cutaneous pseudolymphomas (CPL) with primary cutaneous lymphomas. Review literature in order to improve the treatment of CPL. Six cases of CPLs were collected. The clinical, pathologic, and immunohistochemical features were performed and analyzed in Peking Union Medical College Hospital in 2018. Of six patients, the distributions and clinical manifestations of skin lesions are varied. The pathologic features consisted of atypical prominent lymphocytes infiltration. Of them, two cases imitated mycosis fungoides, one case mimicked primary cutaneous aggressive pidermotropic CD8+ cytotoxic T‐cell lymphoma, one case was diagnosed as Jessner‐Kanof lymphocyte infiltration and two cases primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder. With respect to etiology, one was result from insects bite and the others were on account of drugs. All cases were treated with systemic or local glucocorticoid. The skin lesions and systemic symptoms showed notable improvement after treatment. Follow‐up visits were 2 years, half a year, and months, respectively, without relapse. These unique types of CPL were similar to cutaneous lymphomas in clinical manifestation and pathology. They were all sensitive to the treatment of externally or orally using glucocorticoid. The prognosis is generally good but needs long‐term follow‐up.

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Section: Discussionmentioning

confidence: 99%

Lymphoma or pseudolymphoma: A report of six cases and review of the literature

Zhu

Zhang

Wang

et al. 2019

Dermatologic Therapy

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“…Magro et al suggested that antihistamines may be associated with atypical lymphoid hyperplasia in some patients (24,25). Other drugs that can be involved in cutaneous pseudolymphomatous reactions are angiotensin-converting enzyme (ACE) inhibitors, betablockers, calcium channel blockers, diuretics, cytotoxic agents (ciclosporin, methotrexate), rheumatology drugs (gold, salicylates, phenacetin, D-penicillamine, allopurinol, non-steroidal anti-inflammatory drugs (NSAIDs)), antibiotics, benzodiazepines, procainamide, oestrogens, progesterone and lovastatin (26). In a recent paper by Safa et al (27), a female patient developed erythrodermic CD8 + pseudolymphoma during infliximab treatment and was treated successfully with ciclosporin after cessation of infliximab therapy.…”

Section: Treatment According To Cutaneous Pseudolymphoma Aetiologymentioning

confidence: 99%

“…Treatment consists mainly in the avoidance of the causative allergens. Allergens implicated include phosphorus, N-Isopropyl-N-phenyl-4-phenylenediamine, ethylenediamine, dihydrochloride, cobalt naphthenate, nickel sulphate, paraphenylenediamine, gold sodium thiosulfate, zinc, squaric acid dibutylester, methylchloroisothiazolinone (26). Millican et al reported a first case of CLH after sensitization with squaric acid dibutylester (46)(47)(48).…”

Section: Treatment According To Cutaneous Pseudolymphoma Aetiologymentioning

confidence: 99%

Treatment of Cutaneous Pseudolymphoma: A Systematic Review

Miguel¹,

Peckruhn²,

Elsner³

2018

Acta Derm Venerol

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Cutaneous pseudolymphoma (CPL) is a reactive polyclonal T- or B-cell lymphoproliferative process. CPL may appear as localized or disseminated skin lesions. While most cases of CPL are idiopathic, they may also occur as a response to, for example, contact dermatitis, arthropod reactions, and bacterial infections. CPL can be classified based on its clinical features, but all variants have similar histopathological patterns of either predominantly B-cell infiltrates, T-cell infiltrates, or mixed T/B-cell infiltrates. The prognosis of CPL is good, but the underlying disease process should be taken into account. If an antigenic stimulus is identified, it should be removed. In patients with idiopathic CPL, a close follow-up control strategy should be adopted. The aim of this systematic review is to summarize all reported treatments for CPL. The review was based on articles from the PubMed database, using the query "skin pseudolymphoma treatment", English and German, about "human" subjects, and published between 1990 and 2015 documenting adequate treatment and/or aetiology. Mainly individual case reports and small case series were found. Treatment options include topical and intralesional agents, systemic agents, and physical modalities. The final part of the review proposes a treatment algorithm for CPL according to each aetiology, based on the literature of the last 25 years. Future research should focus on randomized controlled trials and studies on long-term outcomes, which were not identified in the current review.

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“…Spontaneous regression is the most common course of cutaneous lymphoid hyperplasia, but lesions can also remain chronic or recur locally 2,4 . Rare examples of progression to cutaneous lymphoma have been reported, but it remains unclear whether these cases represent actual transformation of a benign lesion or rather an initial misdiagnosis of a malignant lesion 4,6,7 . Although cutaneous lymphoid hyperplasia lesions are often left untreated, possible interventions include antigen removal, excision, topical or injected corticosteroids, local radiation, laser ablation, interferon alpha, and thalidomide 2,4,8 …”

Section: Discussionmentioning

confidence: 99%