“…Data on potential therapy are drawn from isolated case reports, limited case series, and in vitro studies. No prospective clinical studies have been published comparing specific treatments for proto- (27), topical therapy with amphotericin B (61,77,125), ketoconazole (75,85,109), itraconazole (45,80,103,113,145), fluconazole (45,66,80), transfer factor (34), topical amphotericin B with systemic tetracyclines (52,152,157), systemic amphotericin B, with or without excision (66,87,115,116,150), and oral tetracyclines (61,139). Failed treatments involved tetracycline (52), itraconazole (15,86,125), fluconazole (84,115), flucytosine (48,104), and ketoconazole (88,94,115).…”