2010
DOI: 10.1111/j.1600-0560.2009.01449.x
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Cutaneous presentation of post‐renal transplant lymphoproliferative disorder: a series of four cases

Abstract: We report detailed histological and molecular characteristics of four post transplant lymphoproliferative disorders (PTLD) presenting in the skin of renal transplant patients, and their clinical outcome. Three had B-cell lymphomas (cases 1-3), and one had a T-cell lymphoma (case 4). All B-cell lymphomas showed Epstein-Barr virus (EBV) by immunohistochemistry (IHC) or in situ hybridization (ISH). Cases 1 and 2 were large cell lymphomas, and case 3 a plasmacytoma. Case 1 showed light chain restriction and heavy … Show more

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Cited by 36 publications
(27 citation statements)
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“…By contrast, a ‘pyogenic’ picture with numerous neutrophils intermingled with anaplastic cells (a frequent finding in HIV‐associated systemic ALCL) was noted in only two of HIV‐associated primary cutaneous ALCL patients. Such neutrophil‐rich picture has been tentatively attributed to loss of immune system competence in sporadic cases of primary cutaneous ALCL; this inflammatory pattern, however, appears to be an unspecific finding in primary cutaneous ALCL, being detectable in up to 32% of cases in the general population . Of note, IHC positivity for EMA (a rare feature in conventional primary cutaneous ALCL, with only weak/focal expression in less than 30% of cases) was described in up to 75% of tested cases in our review; such finding is rather frequent (approximately 70% of cases) in HIV‐associated systemic ALCL, possibly being a marker of malignant course in combination with lack of ALK1 expression .…”
Section: Discussionsupporting
confidence: 48%
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“…By contrast, a ‘pyogenic’ picture with numerous neutrophils intermingled with anaplastic cells (a frequent finding in HIV‐associated systemic ALCL) was noted in only two of HIV‐associated primary cutaneous ALCL patients. Such neutrophil‐rich picture has been tentatively attributed to loss of immune system competence in sporadic cases of primary cutaneous ALCL; this inflammatory pattern, however, appears to be an unspecific finding in primary cutaneous ALCL, being detectable in up to 32% of cases in the general population . Of note, IHC positivity for EMA (a rare feature in conventional primary cutaneous ALCL, with only weak/focal expression in less than 30% of cases) was described in up to 75% of tested cases in our review; such finding is rather frequent (approximately 70% of cases) in HIV‐associated systemic ALCL, possibly being a marker of malignant course in combination with lack of ALK1 expression .…”
Section: Discussionsupporting
confidence: 48%
“…Multiple characteristics are shared between recipients of allogeneic transplants and HIV‐infected individuals with regard to lymphomagenesis, including increased frequency of incidental NHL, predominance of B‐cell phenotype, tropism for extranodal locations and more aggressive behavior . Allogeneic transplantation also increases the risk of primary cutaneous T‐cell lymphomas, with primary cutaneous ALCL being regarded as the most frequent among primary cutaneous lymphoproliferative disorders of T‐cell phenotype . Interestingly, a multitude of clinicopathological aspects are shared by post‐transplant primary cutaneous ALCL and HIV‐associated primary cutaneous ALCL, so that drawing a parallel between these primary cutaneous ALCL presentations might not be unreasonable (Table ) .…”
Section: Discussionmentioning
confidence: 99%
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“…250,268,269 Primary cutaneous PTLD has also been reported in the literature, 58,255,[270][271][272][273][274][275][276][277][278][279][280][281][282][283] including B-cell and T-cell lymphomas. 250,268,269 Primary cutaneous PTLD has also been reported in the literature, 58,255,[270][271][272][273][274][275][276][277][278][279][280][281][282][283] including B-cell and T-cell lymphomas.…”
Section: Ebv-positive Lymphomas In the Context Of Immunosuppression Pmentioning
confidence: 99%
“…The more intense the immunosuppression used, especially from high doses of anti-T cell immunosuppressive agents, the higher the incidence of PTLD and the earlier it occurs, hence most EBV-related PTLD is in the first year post-transplant. There are several case reports of cutaneous PTLD [16]. Cutaneous presentations are variable and can range from erythematous plaques to ulcerated nodules, occurring in isolation or more generalized.…”
Section: Post-transplant Lymphoproliferative Diseasementioning
confidence: 99%