Cutaneous Phycomycosis (Mucormycosis) With Fatal Pulmonary Dissemination

Veliath, A. J.

doi:10.1001/archderm.1976.01630280037009

Cited by 32 publications

(3 citation statements)

References 8 publications

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“…Hematogenous dissemination is common and the mortality rate has been reported as 70% even after aggressive surgical debridement and amphotericin B administration (19,24,25). Infection in premature infants carries a grave prognosis and is often associated with use of contaminated elasticized bandages or wooden tongue depressors for limb splinting (26–28).…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Zygomycosis in Two Immunocompromised Children

Cantatore-Francis

Shin

Heilman

et al. 2007

Pediatric Dermatology

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Zygomycosis, often referred to as ''mucormycosis'' or ''phycomycosis,'' is a rapidly progressive fungal infection which usually occurs in immunocompromised individuals, and is characterized by soft tissue destruction and invasion of blood vessels. The rare and easily misdiagnosed primary cutaneous form may present as a superficial erosion with a painless, gradual onset and slow progression of symptoms or a gangrenous, necrotic ulceration due to rapid tissue and vascular invasion. With the latter form, the mortality rate among affected individuals is high even after aggressive surgical debridement and amphotericin B administration, emphasizing the importance of early recognition and proper diagnosis. We present two instances of gangrenous cutaneous zygomycosis in immunocompromised children and review the literature with regard to etiology, diagnosis and treatment, highlighting the pediatric population.

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Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Zygomycosis in Two Immunocompromised Children

Cantatore-Francis

Shin

Heilman

et al. 2007

Pediatric Dermatology

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“…Very rarely disseminated disease may arise from localized cutaneous mucor mycosis, which unrecognized results in death. This has been reported in a case of cutaneous mucor mycosis resulting in fatal pulmonary dissemination 5 . Surgical debridement constitutes an essential part of management to remove necrotic skin allowing granulation tissue to develop.…”

Section: Reportmentioning

confidence: 97%

Mucor mycosis infection presenting as a non-healing ulcer in an immunocompromised patient

Lenane

Keane

Loughlin

2003

Clinical and Experimental Dermatology

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Mucor mycosis is an uncommon saprophytic opportunistic fungus causing localized cutaneous infection associated with high morbidity and, on dissemination, high mortality. We report the case of an immunocompromised patient with an aggressively progressing, painful non-traumatic ulceration, unresponsive to standard treatment. Deep biopsies for haematoxylin and eosin staining and fungal culture revealed the characteristic broad non-septate irregular hyphae of mucor allowing introduction of the appropriate treatment. Infection with mucor mycosis must be considered in today's medical environment as the number of immunocompromised patients increases.

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“…4 Preventionofdisseminateddisease can be accomplished by wide local excision of the lesion with primary or secondary skin grafting and intravenous administration of amphotericin B. [5][6][7]…”

Section: Commentmentioning

confidence: 99%