Cutaneous necrotizing small‐vessel vasculitis induced by acute hepatitis E

Viallard, Jean‐François; Vergier, Béatrice; Lazaro, Estibaliz; Greib, C.; Pellegrin, Jean‐Luc

doi:10.1002/ccr3.2167

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Many infectious agents, including HEV, are believed to act as triggers in the pathogenesis of both cutaneous necrotizing small-vessel vasculitis (CNSVV) and Henoch-Schönlein Purpura (HSP). Vessel inflammation may occur as a consequence of direct viral replication, type II or immune complex-mediated (type III) reaction and/or cell-mediated retarded hypersensitivity response (type IV) [ 30 ]. In this context, viral eradication can be useful in reducing clinical manifestations.…”

Section: Hev As a Cause Of Rheumatic Manifestationsmentioning

confidence: 99%

“…One case of HSP occurred in a 6 years old girl with an acute HEV infection [ 40 ], while a case of CNSVV has been described in an adult with evidence of HEV infection [ 30 ]. Both cases had a favorable and self-limiting course requiring only supportive therapy with the resolution of vasculitis after the viral clearance.…”

Section: Hev As a Cause Of Rheumatic Manifestationsmentioning

confidence: 99%

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Hepatitis E Virus and rheumatic diseases: what do rheumatologists need to know?

2020

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Background Hepatitis E virus (HEV) represents the most common cause of acute hepatitis and jaundice in the world. About 2 million of infection cases occur each year in Europe, mainly as autochthonous anthropozoonosis, and HEV can be transmitted through undercooked pork meat. This infection has been linked to various extra-hepatic manifestations, while chronic infections with a rapid development of liver failure have been described in heavily immunosuppressed patients undergoing solid organ transplantations (SOTs), in patients with hematological diseases or with immunodeficiency virus infection. Main body of abstract The purpose of this review article is to describe rheumatic manifestations related to HEV infection and their implications for rheumatologists in the daily clinical practice. Despite recent accumulating literature in this field, little is known about the course of the infection in patients with rheumatic diseases (RDs) and about the impact of immunosuppressive drugs. Moreover, HEV infection can mimic RDs’ manifestations or drugs toxicity. Specific guidelines on management are lacking and the majority of data are referred to SOTs receivers. Conclusions More studies are needed to better understand the real impact of HEV infection in patients with RDs, regarding both clinical outcomes and their management.

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Section: Hev As a Cause Of Rheumatic Manifestationsmentioning

confidence: 99%

Section: Hev As a Cause Of Rheumatic Manifestationsmentioning

confidence: 99%