Cutaneous Myeloid Sarcoma Presenting as Grey Pigmented Macules

Niiyama, Shiro; Amoh, Yasuyuki; Watarai, Akira; Katsuoka, Kensei; Mukai, Hiroyuki

doi:10.2340/00015555-1312

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…Despite multiple reports in the literature, the authors have found no other reported cases of MS presenting with atypical targetoid lesions. [12][13] The atypical targetoid presentation in this patient emphasizes the importance of having a high index of suspicion for MS when a patient with a history of a myeloproliferative disorder presents with any new suspicious cutaneous lesions or eruptions. A thorough work-up should be performed when patients present with new widespread cutaneous lesions, especially on patients who have current or prior history of any hematologic malignancies.…”

Section: Case Reportmentioning

confidence: 83%

Atypical Targetoid Lesions as the Presenting Sign of Myeloid Sarcoma

et al. 2021

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Myeloid sarcoma (MS), also known as chloroma or granulocytic sarcoma, is a rare extramedullary tumor mass that commonly occurs in acute myeloid leukemia (AML). MS may occur before other clinical signs of AML, or alongside other known AML symptoms. MS can also appear in isolation, which makes diagnosis challenging. Clinical knowledge about a typical presentation of myeloid sarcoma is limited, given the heterogeneity in the location and size of MS lesions. We describe a patient with a history of AML who developed an eruption of atypical targetoid purpuric lesions. Diagnostic workup, including laboratory and histologic specimen from the skin were consistent with MS. MS should be suspected in a patient with a history of myeloproliferative disorder who develops atypical targetoid purpuric papules.

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Section: Case Reportmentioning

confidence: 83%