Cutaneous mucormycosis caused by <i>Saksenaea vasiformis</i> in a patient with systemic lupus erythematosus

Sigera, Liyanage Shamithra Madhumali; Gamage, Kavinga Kalhari Kobawaka; Jayawardena, Melani Naamal; Abeydeera, W. P. H.; Malkanthi, Matharage Ariyalatha; Jayasekera, P.I.; Patabendige, C.G.U.A.; Fernando, Arumabaduge Harshini Niranjali

doi:10.1002/ccr3.1698

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…Although rhinoorbito-cerebral involvement is the most common presentation of secondary infections, pulmonary, gastrointestinal as well as cutaneous involvement can occur as well [2,3]. Saksenaea vasiformis, a member of the order Mucorales, is mainly isolated from soil [4]. Unlike other members of the group, it mainly affects cutaneous and subcutaneous tissues following trauma, burns, or lacerations, usually following health care-associated exposures [5].…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Mucormycosis: Case Report

Ayalon¹,

Ibrahim²,

Neumark³

et al. 2020

CRIO

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Treatment with 5-FU cream, an antimitotic agent, is primarily used for the treatment of superficial keratinocytic lesions. This treatment modality has the potential to cause severe localized inflammation with subsequent erythema, pain and crusted erosions. Cutaneous mucormycosis is an opportunistic emerging fungal infection. It is rapidly progressive and affects immunosuppressed or poorly controlled diabetic patients primarily by direct inoculation or secondarily by dissemination. The clinical presentation can be challenging due to its initial nonspecific features and therefore leading to a delay in the diagnosis. Herein, we report a case of mucormycosis of the scalp following treatment with topical 5-FU.

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Section: Discussionmentioning

confidence: 99%

“…The rapid and aggressive progression requires prompt surgical and antifungal treatment [1]. S. vasiformis does not easily sporulate in routine mycological media [4] and requires nutrient-deficient media for growth [10]. Thus, difficulty in diagnosis further delays appropriate treatment and contributes to the high mortality rate [11].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Mucormycosis: Case Report

Ayalon¹,

Ibrahim²,

Neumark³

et al. 2020

CRIO

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“…So far these species (except S. oblongispora ) have been reported worldwide from human and animal clinical cases. They were encountered in tropical and subtropical climates and have been reported from Australia, Thailand, India and Sri Lanka, the Middle East, Tunisia, the USA, Central and South America (1, 12). In Europe, there are only a few published cases available reporting S. vasiformis infections, e.g.…”

Section: Introductionmentioning

confidence: 99%

A New European Species of The Opportunistic Pathogenic GenusSaksenaea–S. dorisiaeSp. Nov.

Labuda

Bernreiter

Hochenauer

et al. 2019

Preprint

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A new species Saksenaea dorisiae (Mucoromycotina, Mucorales), recently isolated 18 from a water sample originating from a private well in a rural area of Serbia (Europe), is 19 described and illustrated. The new taxon is well supported by phylogenetic analysis of the 20 internal transcribed spacer region (ITS), domains D1 and D2 of the 28S rRNA gene (LSU), and 21 translation elongation factor-1α gene (TEF-1α), and it is resolved in a clade with S. 22 oblongispora and S. trapezispora. This fungus is characteristic by its moderately slow growth 23 at 15 and 37°C, sparse rhizoids, conical-shaped sporangia and short-cylindrical 24 sporangiospores. S. dorisiae is a member of the opportunistic pathogenic genus often 25 involved in severe human and animal mucormycoses encountered in tropical and subtropical 26 regions. Despite its sensitivity to several conventional antifungals (terbinafine and 27 ciclopirox), the fungus is potentially causing clinically challenging infections. This is the first 28 novel taxon of the genus Saksenaea described from the moderately continental climate area 29 of Europe.30

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“…So far, these species (except S. oblongispora ) have been reported worldwide from human and animal clinical cases. They were encountered in tropical and subtropical climates and have been reported from Africa (Tunisia), Australia, India, the Middle East (Iraq, Israel, and Saudi Arabia), New Zealand, Sri Lanka, South America (Colombia, Ecuador, and French Guiana), Thailand, and the USA [1, 12, 13]. In Europe, there are only a few published cases available reporting S. vasiformis infections, e.g., from Spain [3, 14–16], France [1, 13], and Greece [2].…”

Section: Introductionmentioning

confidence: 99%

Saksenaea dorisiaesp. nov., a New Opportunistic Pathogenic Fungus from Europe

Labuda

Bernreiter

Hochenauer

et al. 2019

International Journal of Microbiology

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A new species, Saksenaea dorisiae (Mucoromycotina, Mucorales), isolated from a water sample originating from a private well in Manastirica, Petrovac, in the Republic of Serbia (Europe), is described and illustrated. The new taxon is well supported by multilocus phylogenetic analysis that included the internal transcribed spacer (ITS) region, domains D1 and D2 of the 28S rRNA gene (LSU), and translation elongation factor-1α gene (tef-1α), and it is resolved in a clade with S. oblongispora and S. trapezispora. This fungus is characterized by its moderately slow growth at 15 and 37°C, sparse rhizoids, conical-shaped sporangia, and short-cylindrical sporangiospores. Saksenaea dorisiae is a member of the opportunistic pathogenic genus often involved in severe human and animal mucormycoses encountered in tropical and subtropical regions. Despite its sensitivity to several conventional antifungals (terbinafine and ciclopirox), the fungus can potentially evoke clinically challenging infections. This is the first novel taxon of the genus Saksenaea described from the moderately continental climate area of Europe.

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Cutaneous mucormycosis caused by Saksenaea vasiformis in a patient with systemic lupus erythematosus

Cited by 12 publications

References 15 publications

Cutaneous Mucormycosis: Case Report

Cutaneous Mucormycosis: Case Report

A New European Species of The Opportunistic Pathogenic GenusSaksenaea–S. dorisiaeSp. Nov.

Saksenaea dorisiaesp. nov., a New Opportunistic Pathogenic Fungus from Europe

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