Cutaneous metastasis of transitional cell bladder carcinoma: A rare presentation and literature review

Abstract

Cutaneous metastasis from transitional cell bladder carcinoma is a rare clinical entity associated with poor prognosis. We present a case of cutaneous metastasis arising from a transitional cell bladder carcinoma in a male patient who had undergone a radical cystectomy and bilateral ureterostomy 17 months previously. The cutaneous metastasis became evident 3 months before the manifestations of generalized recurrent disease. An awareness of this rare clinical entity and high index of suspicion is needed to rule out metastatic spread in patients with a previous history of transitional cell bladder carcinoma presenting with cutaneous nodules. Definitive diagnosis requires a histological confirmation, but prognosis is generally poor.

Metastatic adenocarcinoma of bladder presenting with skin and visceral metastasis

“…[1][2][3][4][5][6] Cutaneous metastasis of bladder cancer can occur either due to haematogenous/lymphatic spread, direct tumour invasion or as a result of iatrogenic implantation of tumour cells. 1 It may be an initial presenting symptom in advanced cases and can present as nodular, fibrotic and inflammatory lesions.…”

“…1 It may be an initial presenting symptom in advanced cases and can present as nodular, fibrotic and inflammatory lesions. [2][3][4] The presence of skin metastasis confers a poor prognostic sign to the patient as median survival of such patients is <12 months. 2 No definitive therapy is available for the management of metastatic bladder carcinoma to skin.…”

“…5 6 Skin metastasis are usually resistant to available treatment modalities like excision, chemotherapy, radiotherapy and immunotherapy or combination therapy. 3 Cutaneous metastasis of carcinoma bladder has been reported in less than 5% cases. 7 The presence of skin metastasis confers a poor prognostic sign to the patient.…”

Case report. Zeldzame cutane metastasering van urotheelcelcarcinoom twee jaar na cystectomie

“…In uitzonderlijke gevallen kan de huidafwijking gereseceerd worden. Patiënten met gemetastaseerd UCC van de blaas worden vaak behandeld met de combinatie gemcitabine en carboplatine of de combinatie methotrexaat, vinblastine, doxorubicine en cisplatine (MVAC) [1,8]. Van alle tumoren is UCC een van de meest immunogene tumoren wegens de hoge mutatiefrequentie [9], waardoor in toenemende mate immunotherapie met checkpointremmers wordt ingezet.…”

Cutaneous metastasis of transitional cell carcinoma of the urinary bladder: Cytological aspect

“…[1] Cutaneous metastasis from internal malignancies is rare and it may be the first sign of an advanced disease. Overall incidence of documented cutaneous metastases is 5.3% of all cancer patients.…”