Cutaneous Metastasis of Ovarian Cancer on 68Ga-FAPI PET/CT

Ding, Haoyuan; Li, Dan; Chen, Yue; He, Wenfeng; Cai, Liang

doi:10.1097/rlu.0000000000005087

Clin Nucl Med

2024

DOI: 10.1097/rlu.0000000000005087

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Cutaneous Metastasis of Ovarian Cancer on 68Ga-FAPI PET/CT

Haoyuan Ding,

Dan Li,

Yue Chen

et al.

Abstract: Ovarian cancer with cutaneous metastases is quite rare. We report the findings of cutaneous metastases from ovarian cancer on 68Ga-FAPI PET/CT imaging. A 53-year-old woman with cutaneous metastases from ovarian cancer was enrolled in 68Ga-FAPI PET/CT clinical trial. The images showed intense FAPI activity in the known cutaneous metastases.

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2024

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Low expression of ACOT13 predicts poor prognosis and immunotherapy outcome in ovarian cancer

Xie

2024

Am J Transl Res

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Objective: Acyl-CoA thioesterase 13 (ACOT13) is involved in lipid biosynthesis, gene transcription, and signal transduction. We explored the potential of ACOT13 to predict ovarian cancer (OC) prognosis and patient immunotherapy responses. Methods: The Cancer Genome Atlas and Gene Expression Omnibus databases were used to extract raw data. To investigate the potential of ACOT13 as a prognostic and immunotherapeutic marker for OC, bioinformatic analyses were performed using the TIMER website, LinkedOmics database, and R software. We also explored the effects on the invasive ability of OC cells in vitro using a ACOT13 knockdown. Results: The expression of ACOT13 in OC was high and associated with a better prognosis. The expression of ACOT13 was also linked to immune cell invasion immunity-related gene expression. Additionally, immunotherapy was more effective in patients with high ACOT13 expression levels. Multiple critical signaling pathways were found to be involved in the role of ACOT13 in energy metabolism and cell mobility based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. OC cells invaded and migrated significantly more when ACOT13 was knocked down. Conclusion: High ACOT13 expression in OC is associated to a better OC outcome.

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Low expression of ACOT13 predicts poor prognosis and immunotherapy outcome in ovarian cancer

Xie

2024

Am J Transl Res

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Cutaneous Metastasis of Ovarian Cancer on 68Ga-FAPI PET/CT

Cited by 1 publication

References 9 publications

Low expression of ACOT13 predicts poor prognosis and immunotherapy outcome in ovarian cancer

Low expression of ACOT13 predicts poor prognosis and immunotherapy outcome in ovarian cancer

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