Cutaneous Metastasis of Endometrial Cancer and Long-Term Survival: A Scoping Review and Our Experience

Abstract

Background and Objectives: Cutaneous and soft tissue metastases of endometrial cancer are rare. This review aims to examine the prevalence of cutaneous metastasis, the diagnosis and treatment options, and the impact of cutaneous metastasis of endometrial cancer on overall survival. We also present a particular case with a long-term overall survival. Materials and Methods: A systematic literature search was conducted on PubMed and PubMed Central using the following keywords: endometrial carcinoma metastasis, cutaneous metastasis, and five-year overall survival. Results: We identified 326 results and checked their titles for eligibility. There were eight studies included. We also presented a case of a 51-year-old woman with cutaneous metastasis and a large soft tissue metastasis with a prolonged overall survival of about 13 years after the appearance of the first cutaneous metastasis. Conclusions: This paper highlights the importance of skin evaluations in patients diagnosed with endometrial cancer. Healthcare providers must consider the possibility of cutaneous metastasis localization in patients with endometrial cancer to assign the correct stage and apply the appropriate treatment to increase long-term survival.

Inflammatory cutaneous metastases originating from gastric cancer: A case report

“…Cutaneous metastasis occurs in 0.7%-9% of patients with internal cancers[ 3 , 13 , 14 ], usually originating from breast cancer, lung cancer and colorectal cancer[ 13 , 15 ]. Approximately 70% of cutaneous metastases in women are caused by breast cancer[ 16 ].…”

“…The mechanisms of cutaneous metastasis are complex and incompletely understood. Some potential mechanisms include hematogenous, lymphatic, direct invasion and surgical implantation[ 5 , 15 ]. Chemokines and their receptors have been demonstrated to be involved in cutaneous metastasis, but previous findings are still controversial[ 14 ].…”