Cutaneous metastasis of bladder urothelial carcinoma

Hasan, Osamah; Houlihan, Matthew; Wymer, Kevin; Hollowell, Courtney M.P.; Köhler, Tobias

doi:10.1016/j.eucr.2019.101066

Cited by 11 publications

(22 citation statements)

References 4 publications

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“…The presentation of skin metastasis is diverse and can mimic other dermatological disorders, such as urticaria 1 or erythematous or livid, or sometimes painful or infected nodules, as seen in our patient. [2][3][4][5] Cutaneous lesions could also be the first presentation of an undiagnosed primary metastatic cancer of unknown origin. 5 Previous reports show that patients were often first treated according to the clinical diagnosis, before additional skin biopsy showed cutaneous metastasis, which led to delay in accurate diagnosis and treatment.…”

Section: Cutaneous Presentation Of a Bladder Carcinoma Mimicking An Ementioning

confidence: 99%

“…Publication productivity of the 30 countries with the highest absolute number of publications for "dermatology" listed on Scopus (which generated more search hits than PubMed) were determined, normalized to 1 mio inhabitants using United Nations 5 The Scopus search yielded 1,071,518 hits for «dermatology». The top three countries with the highest absolute numbers of publications were the USA, Germany, and the UK, and the highest publication rates normalized per inhabitants were obtained for Switzerland, Denmark, and Sweden.…”

Section: National Publication Productivity In Dermatology: An Exploramentioning

confidence: 99%

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Cutaneous presentation of a bladder carcinoma mimicking an epidermal cyst

2020

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Section: Cutaneous Presentation Of a Bladder Carcinoma Mimicking An Ementioning

confidence: 99%

Section: National Publication Productivity In Dermatology: An Exploramentioning

confidence: 99%

Cutaneous presentation of a bladder carcinoma mimicking an epidermal cyst

2020

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“…A submandibular nodule revealing a relapsed bladder A submandibular nodule revealing a relapsed bladder urothelial carcinoma urothelial carcinoma Aya Khemir 1,2 , Nada Mansouri 1,2 , Faten Gargouri 1,2 , Fethi Bougrine 1,2 , Issam M'sakni 1,2 , Besma Laabidi 1,2 1 Pathology Department, Military Hospital of Tunis, Monfl eury, Tunis, Tunisia, 2 Faculty of Medicine of Tunis, University of Tunis el Manar, Tunis, Tunisia Corresponding author: Aya Khemir, MD, E-mail: dr.ayakhemir@gmail.com Sir Urothelial carcinoma metastases rarely to skin [1,2]. Cutaneous metastasis (CM) from bladder's transitional carcinoma counts less than 1% of all CM from all cancers [1,3]. Bladder cancers are in the second place (17% of cases) after those of kidney in genitourinary tract cancers giving CM [1,3].…”

mentioning

confidence: 99%

“…Cutaneous metastasis (CM) from bladder's transitional carcinoma counts less than 1% of all CM from all cancers [1,3]. Bladder cancers are in the second place (17% of cases) after those of kidney in genitourinary tract cancers giving CM [1,3]. The last may be present at the time of diagnosis or may even occur many years later after treatment [3].…”

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A submandibular nodule revealing a relapsed bladder urothelial carcinoma

Khemir¹,

Mansouri²,

Gargouri³

et al. 2021

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A 69-year-old patient treated for infiltrating bladder transitional carcinoma many years ago presented with a submandibular nodule. The last was fortuitously discovered by the patient a month before he presented to consultation. Physical examination showed a firm subcutaneous nodule of 0.5 cm in diameter in the right submandibular region. At this level skin was inflamed/red and swollen. Otherwise physical examination was within normal. The described nodule above was biopsied. Microscopic examination showed infiltration of the dermis by a carcinomatous proliferation (Fig. 1). Tumor cells were arranged in small nests and clusters surrounded by a fibrous stroma. Tumor cells showed moderate nuclear atypia. Immunohistochemical staining showed positivity of tumor cells for Cytokeratin 7 and P63 (Fig. 2). Therefore, taking into consideration patient’s medical history, microscopic and immunohistochemical findings the diagnosis of CM from urothelial carcinoma was retained. The first case of CM from bladder carcinoma was reported in 1909 [3]. Since then many case have been reported [1,2]. According to cases reported in literature so far, the mean interval of time between the setting of bladder cancer and the appearance of CM is of 18 months approximately. Large tumor size and deep infiltration of the bladder wall are predictive factors of CM. However, cases of CM associated with superficial bladder carcinomas were reported [3]. The certain diagnosis is based on microscopic examination [1,3]. Pathologists should be aware of patient’s medical history to facilitate the diagnosis and choosing appropriate immunostains if necessary especially in front of a poorly differentiated carcinoma[3]. Urothelial carcinomas express Cytokeratin 7 and Cytokeratin 20 antibodies [3]. The occurring of CM in case of bladder cancer darken the prognosis [1,2]. Median survival rates are less than 12 months in published cases so far [1,3]. Treatment consists of chemotherapy if the patient could bare it [1]. Total recovery was detected in 70% of cases of CM treated with chemotherapy. Yet, it does not improve global survival rates [3].

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Cutaneous metastasis emerging during chemotherapy and progressing during immunotherapy for urothelial carcinoma

et al. 2021

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Introduction: Cutaneous metastasis of urothelial carcinoma is uncommon. We experienced a case of cutaneous metastasis that emerged during chemotherapy and progressed rapidly during immunotherapy for bladder tumor with lymph node metastasis. Case presentation: A 77-year-old female patient received chemotherapy using gemcitabine and cisplatin for bladder urothelial carcinoma with para-aortic and pelvic lymph node metastases (clinical stage T2N1M1). After eight courses of chemotherapy, skin rash appeared in the lower abdomen with leg edema caused by multiple lymphadenopathy. Skin biopsy revealed cutaneous metastasis of urothelial carcinoma. The cutaneous tumor progressed rapidly and the patient died 5 weeks after the start of second-line pembrolizumab treatment. Conclusion: A patient with cutaneous metastasis of urothelial carcinoma that emerged during chemotherapy had poor prognosis and lack of efficacy of an immune checkpoint inhibitor.

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Cutaneous metastasis of bladder urothelial carcinoma

Cited by 11 publications

References 4 publications

Cutaneous presentation of a bladder carcinoma mimicking an epidermal cyst

Cutaneous presentation of a bladder carcinoma mimicking an epidermal cyst

A submandibular nodule revealing a relapsed bladder urothelial carcinoma

Cutaneous metastasis emerging during chemotherapy and progressing during immunotherapy for urothelial carcinoma

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