Cutaneous metastasis: a rare phenomenon of colorectal cancer

Wang, Dan Yang; Feng, Yang; Lin, Jian; Xu, Xiao

doi:10.4174/astr.2017.93.5.277

Cited by 34 publications

(56 citation statements)

References 9 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most frequent locations include the abdomen, extremities and chest. Appearances range from single, subdermal flesh-colored to multiple, firm, violaceous nodules [ 3 ]. Mechanisms of cutaneous spread include lymphatic infiltration, intravascular dissemination and direct interstitial infiltration of the dermis [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

A Fall Worth It: Cutaneous Metastatic Deposit of a Distant Colorectal Cancer With Fistula-in-Ano

Badiani

Cooper

Berney

2020

Cureus

View full text Add to dashboard Cite

A seeded fistula-in-ano from a synchronous colon cancer is rare. We report an unconventional case of a 70-year old male who presented with an incidental post-traumatic perianal cutaneous lump following a fall. Lesion biopsy confirmed the presence of a cutaneous malignant deposit. Further workup confirmed the diagnosis of upper rectal adenocarcinoma associated with a fistula-in-ano. The patient underwent long-course neoadjuvant chemoradiotherapy, followed by an “en bloc” laparoscopic abdominoperineal and extended fistula tract resection without complication. This case highlights a rare case of post-traumatic synchronous upper rectal cancer seeding into a low fistula-in-ano tract associated with a cutaneous perianal metastatic deposit.

show abstract

Section: Discussionmentioning

confidence: 99%

A Fall Worth It: Cutaneous Metastatic Deposit of a Distant Colorectal Cancer With Fistula-in-Ano

Badiani

Cooper

Berney

2020

Cureus

View full text Add to dashboard Cite

show abstract

“…The abdomen, particularly at surgical incision scars (both ad hoc surgical scar and preexisting unrelated operative scars), is the most frequent site of cutaneous metastasis of colonic cancer with the pelvis, back, chest, upper extremities, head and neck being the less common ones. This may occur through lymphatic spread, intravascular dissemination, direct extension of tumor, surgical implantation, or spread along embryonal remnants such as the urachus [5].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical features can vary from flesh colored to violaceous, freely mobile to fixed, single to multiple painless to painful nodules, ulcer, bullae, or fibrotic processes [5]. Apart from renal cell carcinoma with its typical histological features, cutaneous metastases do not always permit identification of the primary tumor and immunohistochemical studies are usually required to confirm the primary site [6].…”

Section: Discussionmentioning

confidence: 99%

Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous

Mandzhieva

Jalil

Nadeem

et al. 2020

Cureus

View full text Add to dashboard Cite

Liver represents the most common site of metastasis in patients with advanced colorectal cancer (CRC). Cutaneous metastasis is uncommon and has been documented only in 3% of patients. Most cutaneous metastases demonstrate typical histological features of adenocarcinoma, such as glandular formation and mucin production. We present the case of a 66-year-old male with Crohn's disease (CD) and stage IV rectal signet ring cell carcinoma arising in his rectal stump who presented with a painful papular bilateral groin rash. Biopsy revealed metastatic signet ring cell carcinoma. Since cutaneous metastasis in patients with advanced CRC can be easily confused with infection, especially fungal infection, physicians should be vigilant of the possibility of cutaneous metastasis. Our literature review suggests hematogenous spread as the dissemination pathway of this histological subtype of rectal adenocarcinoma to the skin. We present the first case of cutaneous metastatic signet ring cell carcinoma from a rectal stump of a patient with CD.

show abstract

“…[ 3 , 4 ] Most frequent sites of cutaneous metastasis are the abdomen, inguinal or perineal regions, and prior surgical sites, and occur with less frequency on the face, neck and scalp. [ 5 , 6 ] Adenocarcinoma has the highest rate of cutaneous metastasis compared to other histologic subtypes. The skin metastasis can appear as sessile, pedunculated, single or multiple nodules, as a mass with ulceration, or as a cyst.…”

Section: Discussionmentioning

confidence: 99%

First Case of Topical 5-FU Therapy for Cutaneous Metastasis in a patient with Colon Cancer

Saif

2020

EJMO

View full text Add to dashboard Cite

Cutaneous metastasis from colon cancer is rare, occurs in less than 6% of patients and its associated with poor prognosis. Most often it presents in the abdomen, inguinal or perineal regions, supraclavicular area, and less commonly on the face, neck, scalp, and prior surgical sites. We present a case of a 41-year-old female with colon cancer who developed cutaneous metastases to the scalp, and was treated with topical 5-FU and radiation therapy. Treatment options for cutaneous metastases usually include systemic therapy, topical chemotherapy, surgical excision, or radiation. Our case is probably the first report who was treated with topical 5-FU in addition to radiation therapy. This treatment modality is easy to use and we would recommend clinical trials to be conducted to further study the use of topical 5-FU.

show abstract

Cutaneous metastasis: a rare phenomenon of colorectal cancer

Cited by 34 publications

References 9 publications

A Fall Worth It: Cutaneous Metastatic Deposit of a Distant Colorectal Cancer With Fistula-in-Ano

A Fall Worth It: Cutaneous Metastatic Deposit of a Distant Colorectal Cancer With Fistula-in-Ano

Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous

First Case of Topical 5-FU Therapy for Cutaneous Metastasis in a patient with Colon Cancer

Contact Info

Product

Resources

About