Cutaneous Metastases of Small-Cell Lung Cancer

Abstract

images in clinical medicineT h e ne w e ngl a nd jou r na l o f m e dic i ne n engl j med 354;24 www.nejm.org june 15, 2006 2583A 70-year-old former smoker presented with a history of several weeks of multiple painless cutaneous nodules on his chest wall. He also reported fatigue, weight loss, and cough with blood-tinged sputum. More than 30 subcutaneous nodules were identified on physical examination (Panel A). There was no clubbing, peripheral edema, or joint deformity. The respiratory examination was otherwise normal. Radiography and computed tomography (Panel B) of the chest revealed a mass in the right lower lobe, mediastinal lymph nodes, and multiple cutaneous nodules (arrows). The results of laboratory tests were negative. Levels of rheumatoid factor, complement, antineutrophil cytoplasmic autoantibodies, and carcinoembryogenic antigen were normal. A flexible bronchoscopic examination showed an endobronchial tumor in the right lower lobe. Cutaneous and bronchial biopsy specimens of the tumor were positive for small-cell lung cancer. As in other cancers, the onset of cutaneous metastatic disease in patients with lung cancer is uncommon and indicates a poor prognosis. This patient was treated with systemic chemotherapy but died one month after presentation.

Fluorine-18 Fluorodeoxyglucose PET/CT Images of Hidradenitis Suppurativa Mimicking Metastasis in a Patient With Small Cell Lung Carcinoma

“…It has been reported that metastatic skin lesions spread either via lymphatic or hematogenous route. It is not very common to detect skin metastases in patients with small cell lung cancer, however when it presents a poorer prognosis is expected [16][17][18]. Consequently, histopathological confirmation with biopsy should be performed for suspicious skin or subcutaneous lesions to distinguish metastatic disease.…”

Skin metastases from lung cancer: a case report

“…In our case, facial metastases occurred during chemotherapy. Metastases in skin occur when the disease has progressed and are indicator of poor prognosis and short survival [ 2 , 6 , 13 ]. There are reports that the survival time after the appearance of skin metastases is about 5-6 months [ 3 ].…”

“…Compared to other internal malignancies, lung cancer is the fastest in developing skin metastases after initial diagnosis [ 12 ]. The occurrence of cutaneous metastases from lung cancer is a poor prognostic indicator [ 13 ]. Coexistence of skin metastases with other extracutaneous metastases decreases the average survival time to approximately three months [ 14 ].…”

Множествени Подкожни Метастази От Белодробен Карцином – Рядък Случай В Практиката

“…Кожните метастази от белодробен карцином са рядкост [3][4]. Появата им е признак на авансирало заболяване и е предиктор за ниска преживяемост [5][6]. Данните показват, че след проявата на кожни метастази, продължителността на живота е до 6 месеца [3].…”