Cutaneous Metastases in Neonates: A Review

Isaacs, Hart

doi:10.1111/j.1525-1470.2011.01372.x

Cited by 39 publications

(39 citation statements)

References 33 publications

(80 reference statements)

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“…The usual AT/RT metastases are localised in lungs, liver and other locations in CNS (mainly cerebrospinal pathway). Cutaneous metastases by non-haematopoietic childhood malignancies are rare, and are mainly due to rhabdomyosarcoma and neuroblastoma (10,11). Cutaneous metastases of malignant rhabdoid tumour have only rarely been reported, and the primary tumours were soft tissue and renal RT (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Location of Atypical Teratoid/Rhabdoid Tumour

Bellon

Fraïtag²,

Miquel³

et al. 2014

Acta Derm Venerol

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Atypical teratoid/rhabdoid tumour is a rare and highly malignant tumour of the posterior fossae nervous system that occurs in children especially in the first few years of life. Cutaneous location is not previously reported. A newborn boy was referred for both aqueductal stenosis detected antenatally and skin tags mimicking hamartoma. The cerebral tumour increased in size during a few months leading to both skin and cerebral biopsies. Integrase Interactor-1 (INI-1) immunostaining and tumoural and leukocytes INI-1 gene sequencing confirmed the atypical teratoid/rhabdoid tumour nature of the cerebral tumour. INI-1 immunostaining in skin biopsy confirmed the dermal location of rhabdoid tumour. Thus, unusual cutaneous lesions may be part of atypical teratoid/rhabdoid tumour. The loss of Integrase INI-1 on immunohistochemical staining is characteristic.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Location of Atypical Teratoid/Rhabdoid Tumour

Bellon

Fraïtag²,

Miquel³

et al. 2014

Acta Derm Venerol

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“…Leukemia cutis, presenting as firm nodules, papules or plaques of red, blue or purple color, is a differential diagnosis of the so-called blueberry muffin baby. This syndrome has a diversified differential, ranging from hemato-oncological disorders like Langerhans cell histiocytosis, neuroblastoma, or rhabdomyosarcoma to infectious diseases like rubella, cytomegalovirus infection, or toxoplasmosis to hemolytic disease and blue rubber bleb nevus syndrome [12, 13]. Leukemia cutis has been described as an exclusive manifestation of AML without bone marrow disease [14], as well as appearing prior to or simultaneously with bone marrow involvement [13, 15].…”

Section: Discussionmentioning

confidence: 99%

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

et al. 2016

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BackgroundNeonatal leukemia is a rare disease with an estimated prevalence of about one to five in a million neonates. The majority being acute myeloid leukemia (AML), neonatal leukemia can present with a variety of symptoms including hyperleucocytosis, cytopenia, hepatosplenomegaly, and skin infiltrates. Chromosomal rearrangements including mixed lineage leukemia (MLL) translocations are common in neonatal AML.Case presentationA female neonate born at 34 weeks gestation presented with cardiorespiratory failure, hepatosplenomegaly, pancytopenia, and coagulopathy. She required intensive care treatment including mechanical ventilation, high-dose catecholamine therapy, and multiple transfusions. Small intestinal biopsy obtained during laparotomy for meconium ileus revealed an infiltrate by an undifferentiated monoblastic, MLL-rearranged leukemia. No other manifestations of leukemia could be detected. After spontaneous clinical remission, lasting 5 months without any specific treatment, the patient presented with leukemia cutis and full-blown monoblastic leukemia. MLL-AF10-rearranged AML could be re-diagnosed and successfully treated with chemotherapy and hematopoietic stem cell transplantation.ConclusionsOur patient exhibited a unique manifestation of neonatal MLL-AF10 rearranged AML with cardiorespiratory failure and intestinal infiltration. It highlights the importance of leukemia in the differential diagnosis of neonatal distress, congenital hematological abnormalities, and skin lesions.

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“…Infantile cutaneous manifestation of the disease is extremely rare. Of 208 neonates between 1955 and 2010 with malignancies and cutaneous metastases, only 4 patients (1.9%) had cutaneous metastasis due to choriocarcinoma and it was generally associated with poor prognosis [6]. Approximately one-quarter of infants with choriocarcinoma present with symptoms at birth and diagnosis can be easily confirmed with serum β -hCG [7].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestation of Metastatic Infantile Choriocarcinoma

Brooks

Nolting

2014

Case Reports in Pediatrics

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Infantile choriocarcinoma is a highly malignant rare germ cell tumor that arises from the placenta. Simultaneous intraplacental choriocarcinoma involving both mother and infant is extremely rare. Cutaneous metastasis in infantile choriocarcinoma is even rarer with only a few case reports available. Here we describe a case of a female neonate who presented to the ED with a rapidly growing and bleeding vascular lesion to her right cheek. She was eventually diagnosed by biopsy with metastatic choriocarcinoma. In addition to the cutaneous tumor, she also had metastatic disease in her lungs. Her mother was subsequently found to have choriocarcinoma with metastatic disease to the lungs as well.

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Cutaneous Metastases in Neonates: A Review

Cited by 39 publications

References 33 publications

Cutaneous Location of Atypical Teratoid/Rhabdoid Tumour

Cutaneous Location of Atypical Teratoid/Rhabdoid Tumour

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus

Cutaneous Manifestation of Metastatic Infantile Choriocarcinoma

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