Cutaneous Metastases from Follicular Thyroid Carcinoma: Histology, Immunohistology, and Electron Microscopy

Abstract

Cutaneous metastases from thyroid carcinoma are extremely rare. We report 2 cases of skin metastases from a follicular thyroid carcinoma. A 53-year-old female patient underwent subtotal thyroidectomy because of the clinical suspicion of malignancy. Histological examination of the resected tissue did not clearly prove malignant features. Eight years later a cutaneous metastasis erupted next to the operation site at the neck. A 66-year-old female patient noticed a growing solitary skin nodule in the occipitoparietal region of her scalp 2 years before a follicular thyroid carcinoma was detected.

Scalp metastases from thyroid carcinomas: review of clinical and pathological features

“…[15] Face, neck, chest, arm and pelvis are the other cutaneous sites of metastasis affected with scalp. [16][17][18][19] Eighteen cases of FTC metastasis to scalp were reported in the literature [3,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (Table 1). Two cases reported by Lissak et al [20] were follicular microcarcinoma revealed by solitary scalp lesions.…”

Metástases Cutâneas de Carcinoma de Células de Hürthle da Tiróide

“…[13][14][15][16][17][18] Overall, females outnumber males (12:6); the mean age at presentation is about 65 (41-85), with locations of the skin metastases being the scalp (13 pts), neck (3 pts), face (2 pts) and others (2 pts). [13][14][15][16][17][18] Clinically, they mostly present as asymptomatic skin-colored or red, angioma-like, firm and mobile dermal and subcutaneous papules and nodules that range in size from a few millimeters to several centimeters in diameter and that can occasionally erode and ulcerate both superficially and deeply, into the bone. 19 A vascular appearance has indeed been identified in these lesions, to the point of even showing a pulsatile character upon Doppler echography.…”

Ti̇roi̇d Anaplastik Karsinomlu Bi̇r Olguda Akci̇ğer, Karaci̇ğer, Kemi̇k Ve Ci̇lt Metastazlari

“…Anaplastik karsinomlar için akciğer ve karaciğer beklenen metastaz yerleri olmakla birlikte, eşlik eden yaygın kemik ve cilt metastazı varlığı literatür-de sınırlı sayıda olguda bildirilmiştir (7,10).…”