Cutaneous metastases from different internal malignancies: a clinical and prognostic appraisal

Abstract

The risk of skin metastases depends largely on the characteristics of tumour cells, which is similar among different ethnic groups. In terms of prognosis, a subset of breast cancer patients has superior prognosis, even among breast cancer patients with stage IV disease. Physicians should consider this finding in clinical situations to avoid possible misinformation about the prognosis of the disease.

Cutaneous Metastasis from Cholangiocarcinoma as the First Clinical Sign: A Report of Two Cases

“…The most common presentation of a metastatic skin lesion is a firm, painless nodule (multiple nodules are found in 46.4% of patients and a single nodule in 37.7% of patients; these can be macules, plaques, erythematous plaques, and ulcers). 3 Previous reports indicate that the most common presentation of cutaneous metastases of cholangiocarcinoma is the nodular type; other skin lesions described include erythematous plaques, abscesses, and ulcers. [4][5][6][7][8][9][10][11] Most nodular lesions are firm, painless, and nonulcerative and covered by a normal appearing epithelium; this results in some lesions being misdiagnosed as benign.…”

“…Hu et al 3 reported that the majority of patients (73.8%) with skin metastases had concomitant visceral metastases at the time of, or following cutaneous presentation. The two previously reported patients who presented with cutaneous metastases of cholangiocarcinoma, as well as the two patients described here, all died within 7 months of the diagnosis.…”

“…3 Lookingbill et al 11 found that scalp metastases originated from a wide variety of cancers, including lung, renal, and hematopoietic malignancies. In the case of cholangiocarcinomas, the two previously reported patients, and those in our case studies, had a metastatic skin lesion on the scalp.…”

“…3 Cholangiocarcinoma is a neoplasm of the bile duct, which frequently invades or metastasizes to adjacent organs or other visceral organs, such as the lungs, bones, adrenal glands, and brain. 4,5 Cutaneous metastases of cholangiocarcinoma are extremely rare and have been reported to occur in only 0.4-5.3% 6,7 of cases.…”

Cutaneous Metastases of Internal Malignancies: A Retrospective Study from a Tertiary Care Centre in Sub-Himalayan Region

“…CM lesions are usually multiple and may range from 1 to 100. [7] In our study only one patient of because normally cutaneous metastasis occurs in later stages of disease when it has become widely disseminated in the lymphohaematogenous route. Skin-coloured to erythematous nodules at multiple sites were the most common clinical presentation of cutaneous metastases seen in 57.1% patients.…”