Cutaneous metastases from adenocarcinoma of the ovary

McDonald, Heidi; Moore, Milton R.; Meffert, Jeffrey J.

doi:10.1016/j.jdcr.2016.08.010

Cited by 7 publications

(10 citation statements)

References 6 publications

(10 reference statements)

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“…They can occur with the direct spread of malignant cells within the abdominal cavity or via lymphatic vessels (13). Although pleura, liver, bone, lung, and lymph nodes are common sites of distant metastasis, cutaneous metastases are rare in ovarian malignancies (10). Nowadays the main treatment for advanced stages of dysgerminoma, eg, disease with extra-ovarian spread, is post-operative adjuvant chemotherapy with carboplatin or cisplatin in combination with etoposide and bleomycin (14).…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic Resonance Imaging (MRI) could help distinguish these, though pathologic specimens are essential for ultimate diagnosis (9). The most common ovarian tumor which metastasizes to the skin is epithelial adenocarcinoma (serous, mucinous, and endometrioid) (10). Dysgerminoma is the most common ovarian germ cell tumor that may have a local invasion, lymphatic spread to pelvic lymph nodes, or hematogenous metastases (11).…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastasis in a Previously Known Case of Ovarian Dysgerminoma: A Case Report

et al. 2021

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Introduction: Cutaneous metastasis is an uncommon manifestation that mostly occurs in patients with previous gastrointestinal or gynecological malignancies. Local recurrence usually can be seen in surgical incisions. Dysgerminomas are rare ovarian tumors that usually have local invasions, but metastases are infrequent. Here, we described a case of dysgerminoma and cutaneous metastasis in the surgical incision. Case Presentation: The patient was a 39-year-old woman previously known as ovarian dysgerminoma, who had undergone surgery one year ago. Ultrasound examination a year after surgery showed a 35 × 33 millimeters hypoechoic solid tumor in the left ovary and another 3 masses with similar echo pattern and vascularity were found in the surgical incision. Magnetic resonance imaging (MRI) findings were compatible with cutaneous metastasis of pervious dysgerminoma. Pathologic evaluation and Immunohistochemistry (IHC) confirmed dysgerminoma's skin metastasis. She received chemotherapy due to the recurrence of malignancy. Conclusions: Local recurrence and metastases (even in the skin) should be kept in mind and the clinician must examine the surgical site skin in patients with a history of malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastasis in a Previously Known Case of Ovarian Dysgerminoma: A Case Report

et al. 2021

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“…Cutaneous metastases are estimated to occur in 2% to 5% of patients with ovarian tumors, and portend a poor prognosis. [85][86][87] In one series, the most commonly reported ovarian variant to metastasize was serous papillary cystadenocarcinoma (78%), followed by endometrioid and mucinous variants. 85 Clinically, the majority of patients present with crops of multiple erythematous nodules involving the chest or abdomen, with multiple reports of seeding occurring in laparotomy scars or trocar port sites.…”

Section: Gynecologicmentioning

confidence: 99%

Cutaneous Metastases: A Review and Diagnostic Approach to Tumors of Unknown Origin

Habermehl

2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Cutaneous metastases from a distant malignancy are a diagnostic challenge for pathologists. Secondary involvement of the skin by a metastatic process portends a much worse clinical prognosis than any primary cutaneous malignant mimickers. Immunohistochemical staining methods continue to evolve and are of paramount importance in diagnosis. Objective.— To review the clinical, histopathologic, and immunohistochemical staining patterns for commonly encountered entities and discuss potential pitfalls in diagnosis. A practical guide useful in approaching cutaneous metastases of unknown primary is outlined. Data Sources.— An extensive search and review of literature in PubMed was performed, processed, and condensed. Conclusions.— Cutaneous metastases have broad histopathologic patterns. They are nearly always dermal based, with an overall foreign appearance. They can be single papules/nodules or multiple in number, mimicking an inflammatory or infectious process. Ultimately, immunohistochemistry remains an essential diagnostic tool, and clinical correlation is paramount in the workup of these entities.

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“…Cutaneous metastasis is an uncommon manifestation of internal malignancy, occurring in 0.9% to 5.8% of patients with ovarian carcinoma [5][6][7]. Up to this date, to the best of our knowledge, there is no report of PPCCC with cutaneous metastasis.…”

Section: Introductionmentioning

confidence: 96%

Cutaneous and Cerebral Metastases From Primary Peritoneal Clear Cell Carcinoma

Alves¹,

Malheiro²,

Ferreira³

et al. 2022

Cureus

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Peritoneal tumors are very uncommon and among them, primary peritoneal clear cell carcinoma is extremely rare and often misdiagnosed as others subtypes. There are only 13 cases of primary peritoneal clear cell carcinoma previously reported in the literature and there are no reports about cutaneous metastasis in this setting and only brain metastases were described to be associated with other primary peritoneal carcinoma subtypes. More information about this topic is needed and so we are presenting a new case of primary peritoneal clear cell carcinoma with cutaneous and cerebral metastases in a 34-year-old female.

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Cutaneous metastases from adenocarcinoma of the ovary

Cited by 7 publications

References 6 publications

Cutaneous Metastasis in a Previously Known Case of Ovarian Dysgerminoma: A Case Report

Cutaneous Metastasis in a Previously Known Case of Ovarian Dysgerminoma: A Case Report

Cutaneous Metastases: A Review and Diagnostic Approach to Tumors of Unknown Origin

Cutaneous and Cerebral Metastases From Primary Peritoneal Clear Cell Carcinoma

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