Cutaneous metastases: clinical and dermatoscopically simulating multiple dermatofibromas

Rodríguez-Martín, A.M.; Ruano-Ruiz, Juan; Vélez-García-Nieto, Antonio

doi:10.1111/ijd.12895

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…The morphology of metastatic skin lesions from breast carcinoma is diverse (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The most common presentation of breast cancer cutaneous metastases are nodules on the ipsilateral chest wall and breast; however, the skin metastases can also appear as papules or plaques.…”

Section: Discussionmentioning

confidence: 99%

“…Benign cutaneous lesions and tumors [1][2][3][4][5][6] Collision tumor [3,4] Cyst [2] Dermatofibroma [5] Milia-en-plaque [6] Nodule…”

Section: Condition Referencesmentioning

confidence: 99%

“…It is also a common neoplasm associated with cutaneous metastases. The morphology of the skin lesions secondary to metastatic breast cancer is variable in appearance [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Appearance of Breast Cancer Cutaneous Metastases

Cohen¹

2021

Cureus

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Cutaneous metastases occur in approximately 10% of oncology patients as a feature of a persistent solid tumor or the harbinger of recurrent neoplastic disease. However, they can be the presenting manifestation of an unsuspected visceral malignancy in one percent of previously cancer-free individuals. Metastatic skin lesions from breast carcinoma are diverse in their appearance. The clinical presentation of cutaneous metastases in three women with breast cancer is described and both the morphology of skin metastases caused by breast carcinoma and the conditions that are mimicked by breast cancer cutaneous metastases are reviewed. Skin metastases from breast carcinoma commonly appear as firm, flesh-colored to red, smooth or ulcerated or crusted, nodules, papules, and plaques on the ipsilateral chest wall and breast. However, unique sites of breast cancer cutaneous metastases are the eyelids, inframammary folds, ipsilateral lymphedematous arm, scalp, subungual nail bed, and umbilicus; in addition, skin metastases can occur in mastectomy scars and radiation therapy ports. Carcinoma erysipelatoides, carcinoma telangiectoides, and carcinoma en cuirasse are classic patterns of skin metastases that can be observed in breast cancer patients; carcinoma hemorrhagiectoides is a recently observed skin metastases pattern that has also been noted in oncology patients with breast carcinoma. The pleomorphic skin lesions of breast cancer metastases can masquerade as benign cutaneous lesions and tumors (such as a collision tumor, cyst, dermatofibroma, and milia-en-plaque), cutaneous malignancies (such as melanoma and non-melanoma skin cancers), infections (such as cellulitis, folliculitis, herpes zoster, and paronychia), reactive erythema (such as erythema annulare centrifugum, and urticaria), skin conditions (such as alopecia areata, dermatitis, hidradenitis suppurativa, and scleroderma), and vascular lesions (such as angiokeratoma, angiosarcoma, lymphangioma circumscriptum, purpura, and pyogenic granuloma). In addition, breast carcinoma cutaneous metastases can not only mimic other miscellaneous conditions such as erosions and ulcers, Paget's disease, and papillomatosis cutis lymphostatica but also have unusual morphology such as targetoid lesions or a sharply demarcated red infiltration of the nasal tip similar to a clown's nose. The possibility of a breast cancer cutaneous metastasis should be considered in the evaluation of a patient with breast cancer--and although less likely, in a cancer-free individual--who develops a new and/or a treatment-unresponsive cutaneous lesion. A biopsy of the skin lesion is necessary to confirm the diagnosis of breast cancer cutaneous metastasis.

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Section: Discussionmentioning

confidence: 99%

“…Benign cutaneous lesions and tumors [1][2][3][4][5][6] Collision tumor [3,4] Cyst [2] Dermatofibroma [5] Milia-en-plaque [6] Nodule…”

Section: Condition Referencesmentioning

confidence: 99%

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Pleomorphic Appearance of Breast Cancer Cutaneous Metastases

Cohen¹

2021

Cureus

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“…A wide spectrum of clinical presentations has been described, including nodules, papules, plaques, tumors, and ulcers [2]. Most lesions appear as a discrete firm painless nodule [3].…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous metastases are relatively rare in clinical practice, occurring in 0.7% -9.0% of patients with internal neoplasms depending on the series [3]. Breast cancer is among the neoplasms that show a great tendency to spread to the skin.…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer Cutaneous Metastasis after Scalp Cooling for Alopecia Prevention

Gomes¹,

Ferreira²,

Karani³

et al. 2020

JCT

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Scalp cooling is a widely used method to prevent chemotherapy-induced transient alopecia. Although the success rates in maintaining hair can be high, authors have expressed their concerns regarding the risk of scalp metastasis after scalp cooling. We report a case of breast cancer scalp metastasis in a patient submitted to scalp cooling for alopecia prevention and discuss the physiopathology, risks and benefits of this treatment for patients under this treatment.

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