Cutaneous markers of systemic manifestations of tuberous sclerosis complex

Galahitiyawa, Januka; Wanigasinghe, Jithangi; Seneviratne, Jayamini; Galahitiyawa, Mahel Chintana Bandara

doi:10.1111/ijd.12636

Cited by 1 publication

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References 4 publications

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“…However, the small number of patients enrolled in each of these pathology subgroups in our study, weakened the clinical value of our results. As has been pointed out, the list of diseases that are going to give CALS as cutaneous manifestations is very broad, and continues to grow with the new findings of genetics in which new mutations simultaneously associate cutaneous and CNS manifestations [4,[11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

Carratalá-Marco¹

2017

OAJNN

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Introduction:The Café au lait spots (CALS) are shown in the normal population without pathological significance, although they could also be criteria for some neurologic syndromes. Unspecific association with general neurologic illnesses has been less frequently described. We want to know in which measure, the presence of isolated CALS represents a risk factor for neurological disease. Patients and methods:We set up an observational transversal study of cases, patients admitted for neuropaediatric reasons (NPP; n=49) excluding all the patients suffering from neurologic illnesses associated to CALS, and controls, a hospital simultaneously admitted pediatric population for non-neurologic causes (CP; n=101) since October 2012 to January 2013. The data were collected from the clinical reports at admission, and then analyzed by SPSS 22.0 statistical package, and the Stat Calc module of EpiInfo 7.0, following the ethics current rules of the institution for observational studies.Results: Twelve out of 49 NPP (24.4%) showed at least one CALS, while only 10 out of 101 PC (9.9%) (OR= 4.38; IC=1.03-19.74) did it, being the probability of showing CALS at least 4 times significantly higher in the NPP group than in the CP group. The epileptic patients (Χ2=14.19; p=0.0002) and those admitted for encephalopathy studies (Χ2=45.7; p=0.000000) showed a significantly higher prevalence of de CALS. Conclusion:The prevalence of CALS was significantly higher among the patients admitted because of neurologic problems excluding syndromes or illnesses associated to them.

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Section: Discussionmentioning

confidence: 99%

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

Carratalá-Marco¹

2017

OAJNN

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Cutaneous markers of systemic manifestations of tuberous sclerosis complex

Cited by 1 publication

References 4 publications

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

Café Au Lait Spots as a Marker of Neuropaediatric Diseases

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