Cutaneous Markers of Internal Malignancy

Clinicopathological study of neurofibromatosis type 1: an experience in Nigeria

“…19 Minor disease features such as short stature and macrocephaly, reported by North et al . 3,5,12,17,20 Rapid growth of a plexiform or subcutaneous neurofibroma, especially when associated with neurological Figure 3 showing dense cellularity composed of spindle cells with hyperchromatic nuclei (H&E ×165) deficit, usually suggests the development of neurofibrosarcoma; the most dreaded complication of this disease. Recognized disease complications of NF1 include plexiform neurofibroma, optic gliomas, scoliosis and learning disability.…”

“…3 That the three cases (3.1%) of neurofibrosarcoma developed from preexisting neurofibromas in our patients correlates with the finding of 1%,3%, and 3.1% incidences, respectively, in other studies. 3,5,12,17,20 Rapid growth of a plexiform or subcutaneous neurofibroma, especially when associated with neurological Figure 3 showing dense cellularity composed of spindle cells with hyperchromatic nuclei (H&E ×165) deficit, usually suggests the development of neurofibrosarcoma; the most dreaded complication of this disease. Neurofibrosarcoma associated with NF1, usually arises de novo , rather than from preexisting neurofibroma.…”