Cutaneous Manifestations of Systemic Lupus Erythematosus

Tuffanelli, Denny L.; Dubois, Edmund L.

doi:10.1001/archderm.1964.01600040005001

Cited by 175 publications

(51 citation statements)

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“…Bullous LE and maculopapular eruption was reported higher in present study than described by Cardinal et al 10 They found only one cases among 186 patients had bullous LE and one had maculopapular eruption. Hyperpigmentation was noted 20% of our study which is consonance with Rabbani et al 2 but differ from Tuffanelli et al 21 where they note it is 8.4%. This difference could be due to excessive exposure to sunlight in our subcontinent and a general tendency to post inflammatory melanosis.…”

Section: Discussionsupporting

confidence: 84%

Cutaneous Manifestations of Systemic Lupus Erythematosus

et al. 1970

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Systemic lupus erythematosus (LE) is a heterogeneous, multisystem, autoimmune disease characterized by the production of auto-antibodies against several cell constituents. The skin is one of the target organs most variably affected by the disease can be yield valuable diagnostic & prognostic information. The present study was conducted to evaluate cutaneous manifestations of SLE in Bangladeshi patients. 100 cases of SLE were collected from the Department of Dermatology, BSMMU, Dhaka. The diagnosis was based on American Rheumatism Association Criteria. Cutaneous changes were recorded on a predevised pro forma. LE specific cutaneous changes noted were: Malar rash or butterfly rash (70.0%), maculopapular rash (19.0%), discoid rash (10.0%), and bullous LE (10.0%). Non specific LE lesions noted were: Photosensitivity (75.0%), alopecia (47.0%), oral mucosal lesion (34.0%), hyperpigmentation (20.0%), nail change (15.0%), Raynauds phenomenon (12.0%), Palmar erythema, genital lesion, periungual talangiectesia, leg ulcers, livedo reticularis, erythema multiform were rare. Systemic lupus erythematosus is a multisystem disease that predominantly affects women. Cutaneous lesions are the most important diagnostic tools as reflected by the fact that they account for four of the 11 revised American Rheumatism Association criteria of SLE. The pattern of skin changes may vary from place to place. Key Words: SLE, LE specific and non specific cutaneous lesions Â DOI = 10.3329/jom.v8i2.1405 J MEDICINE 2007; 8 : 44-48

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Section: Discussionsupporting

confidence: 84%

Cutaneous Manifestations of Systemic Lupus Erythematosus

et al. 1970

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“…The higher prevalence of Raynaud's phenomenon in our patients may reflect the interest in this manifestation at our center, and the careful historical search for it incorporated in the detailed protocols of this prospective study. The prevalence of facial erythema and positive LE cell tests was higher in the ARA criteria group than in our patients, but the ARA criteria frequency was also higher than reported in two large series (4,5) and in two other patient groups to which the criteria have recently been applied (6,7). This may be the result, as suggested by Fries and Siege1 (7), of having selected patients with "classical" manifestations of SLE and RA for the study groups from which the criteria were derived.…”

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confidence: 64%

Preliminary criteria for the classification of systemic lupus erythematosus (SLE) evaluation in early diagnosed SLE and rheumatoid arthritis

Trimble

Townes

Robinson³

et al. 1974

Arthritis & Rheumatism

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Preliminary criteria for the classification of systemic lupus erythematosus (SLE) were applied to patients with early diagnosed SLE and rheumatoid arthritis (RA) who are participants in a prospective community study of arthritis of recent onset. Sensitivity of the criteria was 88 % , and specificity against RA was 97.5 ye. Sensitivity increased to 92 % without loss of specificity when high titer antinuclear antibody (ANA) was used as an alternative criteria manifestation to LE cells. These results show the efficacy of the proposed criteria for early diagnosed patients, and support the inclusion of high titer ANA in the SLE criteria.Recently published preliminary criteria for the classification of systemic lupus erythematosus (SLE) (1) were applied to 25 patients with a clinical diagnosis of SLE, and to 40 patients with a clinical diagnosis

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“…In some large-population studies, acute skin lesions were observed in 30-60% of SLE patients [4,5], The higher percentage (89%) in our study could be explained by two factors: (1) the total SLE patient population in the present study was limited to those with LE-specific skin lesions, while those in other studies ad ditionally contained patients without LE-specific skin dis eases, and (2) patients with acute lupus skin lesions in our study included those with both malar rash and analogous skin lesions on other sites of the body. We reconfirmed that the acute skin lesion was a reliable cutaneous marker of systemic involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, discussion mainly focused on the association between only one type of lupus skin lesions and extracutaneous manifestations [3][4][5][6][7][8][9][10][11][12][13], and the coexistence of other skin lesions was not systematically considered. In this study, we analyzed the prevalence of the 1982 ARA criteria for SLE from a purely dermatological perspective.…”

Section: Introductionmentioning

confidence: 99%

Classification of Lupus erythematosus Based upon Cutaneous Manifestations

Watanabe

Tsuchida

1995

Dermatology

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Background: Lupus erythematosus (LE) is a multi-organ-system disease, the characteristics of which are reflected in the 1982 American Rheumatism Association (ARA) criteria for systemic lupus erythematosus (SLE). From a dermatological point of view, only the presence of LE-specific histopathology is necessary and sufficient for the diagnosis of LE. The association between the type of LE-specific skin lesion and the severity of extracutaneous manifestations of LE has not yet been investigated systematically. Objective: The aim of this study was to evaluate, according to the type of LE skin lesions, the prevalence of the 1982 criteria for SLE. Methods: We selected 191 patients whose skin lesions were histologically diagnosed as LE specific. Patients were classified on the basis of skin disease, and their clinical and laboratory data were analyzed. Results: Of 191 patients, 130 (68%) exhibited only one type of LE-specific skin lesion (monomorphic), 55 (29%) had two types (bimorphic) and the remaining 6 (3%) displayed three types (trimorphic). Nineteen of 22 (86%) patients who presented discoid lupus skin lesions above the neck without other eruptions were classified in the cutaneous-limited LE spectrum. Of 116 patients with acute lupus skin lesions (malar rash), 83 (72%) clearly fulfilled the 1982 ARA criteria for SLE. In skin lesions of LE profundus, chilblain lupus, subacute lupus (annular-polycyclic erythema and the papulosquamous variant), there were no significant correlations between the type of eruption and the severity of extracutaneous manifestations. Conclusion: Patients with acute lupus skin lesions could usually be classified as suffering from SLE, whereas monomorphic patients with localized discoid lesions rarely exhibited extracutaneous manifestations. This tendency was less distinct in bimorphic patients. Almost all patients with subacute skin lesions were bimorphic or trimorphic, which might be due to genetic or racial differences between Japanese and other populations.

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Cutaneous Manifestations of Systemic Lupus Erythematosus

Cited by 175 publications

References 15 publications

Cutaneous Manifestations of Systemic Lupus Erythematosus

Cutaneous Manifestations of Systemic Lupus Erythematosus

Preliminary criteria for the classification of systemic lupus erythematosus (SLE) evaluation in early diagnosed SLE and rheumatoid arthritis

Classification of Lupus erythematosus Based upon Cutaneous Manifestations

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