Cutaneous Manifestations of Multiple Myeloma

Abstract

We report the cutaneous manifestations of multiple myeloma, using a retrospective review of 115 patients' records obtained from tumor registry files. Five patients were found to have biopsy-proved extramedullary plasmacytomas without extension from an underlying bony focus. Twelve patients had ecchymoses without thrombocytopenia; two of them had biopsy-proved amyloidosis. One patient presented with pyoderma gangrenosum and was subsequently diagnosed with multiple myeloma. The last patient initially presented with what clinically appeared to be leukocytoclastic vasculitis, and, in the course of a standard workup, he was diagnosed with multiple myeloma. These findings are discussed with regard to the current literature on the cutaneous manifestations of multiple myeloma.

Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review

“…There are several lines of evidence supporting an immunologic etiology of PG. For one, as mentioned above, patients often have a coexisting immunemediated disease such as IBD or inflammatory arthritis (RA, ankylosing spondylitis, or other seronegative arthritis) (23)(24)(25)(26)(27)(28)(29)(30). Second, patients treated with immune modifying medications for other conditions rarely develop PG; for example, there have been separate case reports of patients developing PG in the setting of infliximab or granulocyte-macrophage colony-stimulating factor (GMCSF) therapy (31,32).…”

Dermatose neutrophilique aiguë induite par le bortezomib

“…L'implication de nombreux médicaments a été rapportée, les facteurs de croissance granulocytaire étant les plus fréquemment incriminés [8]. L'apparition d'un syndrome de Sweet au cours de l'évolution spontanée d'un myélome multiple est rare, avec seulement deux cas rapportés dans la littérature [9,10] ; d'autres cas seraient secondaires à l'administration de facteurs de croissance granulocytaire [8,11]. Nous retenons chez notre patient le diagnostic de syndrome de Sweet, malgré l'absence de fièvre et d'hyperleucocytose, en raison de l'aspect clinique compatible et surtout de l'examen anatomopathologique tout à fait évocateur, montrant un derme oedémateux siège d'un infiltrat inflammatoire riche en polynucléaires neutrophiles.…”

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

“…The nonspecific manifestations include a cutaneous finding owing to the abnormal level of proteins (amyloid, cryoglobulins), cytopenia (anemia, thrombocytopenia, and leukopenia), and involvement of internal organs (kidney, lungs, nerves, and ganglion). Since Bluefarb's publication, other cutaneous manifestations of multiple myeloma have been described, including pyoderma gangrenosum, 4,5 leukocytoclastic vasculitis, Sweet's syndrome, subcorneal pustular dermatosis, POEMS ( p olyneuropathy, o rganomegaly, e ndocrinopathy, m onoclonal gammopathy, s kin changes) plane xanthoma, scleromyxedema, waldenström macroglobulinemia cutis, amyloidosis, and cryoglobulinemias 6–8 . Plasmacytoma is characterized by a proliferation of neoplastic plasma cells in the tissue.…”

“…Various cutaneous lesions have been associated with multiple myeloma. Fluefarb has classified them as specific lesions and nonspecific lesions 3,4 …”