Cutaneous manifestations of internal malignancies

Brenner, Sarah; Tamir, Einat; Maharshak, Nitsan; Shapira, Jeremiah

doi:10.1016/s0738-081x(01)00174-2

Cited by 50 publications

(50 citation statements)

References 71 publications

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“…Histology revealed a variable morphological differentiation, the cells are undifferentiated and frequently do not allow the recognition of the primary tumor [1]. They rarely keep the histological characters recognizable of the primary tumor.…”

Section: Resultsmentioning

confidence: 95%

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Cutaneous Metastases of Internal Cancers: A Retrospective Study about 12 Cases

Oualla¹,

Arifi²,

Mellas³

et al. 2012

JCST

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The skin is an uncommon site of metastasis of the internal cancers. The majority of cutaneous metastases are diagnosed after the primary cancer; but they can be the telltale sign of an unknown malignancy. They represent a sign of poor prognosis with a survival rate not exceeding a few months. We report the results of a retrospective study conducted in department of medical oncology at Hassan II University Hospital, including 12 patients with cutaneous metastases. The aim of this work is to show the rarity of skin as metastatic site, to analyze the clinical aspects of cutaneous metastasis, the most criminalized primary cancers and the prognosis value of this metastatic localization.

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Section: Resultsmentioning

confidence: 95%

“…The occurrence of cutaneous spread of internal malignancies is quite rare, despite the fact that the skin is one of the largest organs of the human body [1,2]. The frequency of cutaneous metastases is low, ranging from 0.3 to 9% according to the literature [3].…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Metastases of Internal Cancers: A Retrospective Study about 12 Cases

Oualla¹,

Arifi²,

Mellas³

et al. 2012

JCST

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“…Together with the subheadings organ speciWc reviews as far as available are cited. Summarizing overviews are given in Braverman (2002), Brenner et al (2001), Brownstein and Helwig (1972a, 1972b, 1973, Lookingbill et al (1990Lookingbill et al ( , 1993, Schoenlaub et al (2001). …”

Section: Clinical Picturementioning

confidence: 99%

Cutaneous metastases of visceral tumours: a review

Nashan

Müller

Braun‐Falco

et al. 2008

J Cancer Res Clin Oncol

116

136

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“…14 In some cases of paraneoplastic syndrome in humans, an association between a specific cancer and a specific dermatitis is described. 2 In cats an example of paraneoplastic dermatopathy is ventral alopecia and ''glistening skin,'' which has been observed in association with pancreatic carcinoma or bile duct adenocarcinoma. 12,17 A similar correlation seems to occur in cats, where thymomas are typically associated with a nonpruritic, generalized exfoliative dermatitis.…”

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confidence: 99%

Thymoma-associated Exfoliative Dermatitis in Cats

Rottenberg¹,

Tscharner²,

Roosje³

2004

Vet Pathol

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Abstract. Five cases of exfoliative dermatitis in cats were presented from 1996 to 2002 in which a feline thymoma was found by postmortem or postsurgical examination. Besides abundant exfoliation of keratin squames and layers, the histologic picture of the skin revealed a similar pattern of interface dermatitis with predominantly CD3ϩ lymphocytes and fewer mast cells and plasma cells. In the epidermal basal layer a hydropic degeneration of keratinocytes was present. In all cases an infundibular lymphocytic mural folliculitis and absence of or drastic decrease in the number of sebaceous glands occurred. In addition to the so far described cell-poor type, we also found examples of a cell-rich skin lesion. Together with the clinical observation of generalized exfoliative dermatitis, the histologic pattern of this dermatitis was suggestive of an underlying thymoma. The pathogenesis of this skin disease in association with thymic neoplasia remains obscure, and our results contradict the hypothesis of production of autoantibodies that cross-react with epithelial antigens. The morphology of the thymomas and CD3 expression of the thymocytes varied and did not seem to have an impact on the dermal lesions.

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Cutaneous manifestations of internal malignancies

Cited by 50 publications

References 71 publications

Cutaneous Metastases of Internal Cancers: A Retrospective Study about 12 Cases

Cutaneous Metastases of Internal Cancers: A Retrospective Study about 12 Cases

Cutaneous metastases of visceral tumours: a review

Thymoma-associated Exfoliative Dermatitis in Cats

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