Cutaneous Manifestations of Chronic Liver Disease

Patel, Anna; Katz, Kimberly; Gordon, Kenneth B.

doi:10.1016/j.cld.2020.04.003

Cited by 7 publications

(6 citation statements)

References 60 publications

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“…The present study showed statistically significant associations between skin rash in sun-exposed areas with hepatic diseases (p = 0.04), and in the study of Bansal, S., et al, (36), also the skin rash in sun-exposed areas was significantly higher in hepatic disease (49.1%). In patients with diabetes mellitus, there was impaired night vision (p = 0.001), and paresthesia (p = 0.01), which was in agreement with Beran, R., et al, (31), as the paresthesia was the most presented symptom in the diabetic elderly population.…”

Section: Figure (1)supporting

confidence: 74%

Screening of Nutritional Deficiency Manifestations Among Egyptian Elderly: Cross-sectional study

al.¹

2022

The Egyptian Journal of Geriatrics and Gerontology

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Background: Nutritional deficiencies are frequently not detected or misdiagnosed in old age as they could mimic the natural changes associated with aging Aim: To screen the clinical manifestations of nutritional deficiencies among the elderly . Method: A cross-sectional study was conducted on 100 elderly participants with chronic diseases, aged 65 or more, chosen randomly from the outpatient clinic and inpatient at Menoufia university hospital, Egypt. Tools of the study: Demographic and clinical data; a checklist of symptoms and signs of common nutritional deficiency; and a subjective global assessment (SGA).Results: the distribution of potential nutritional clinical manifestations among elderly revealed was variable ; skin rash (29%), easy bruising (41%), loss or thinning of hair (75%), spooning of nails (20%), impaired vision at night (37%), clouding and corneal dryness.(57%), bleeding gums (56%), bone deformities (bowlegs, knocked knees, curved spine) (6%), bone tenderness (49%). There were statistically significant difference between SGA and the following chronic diseases: (DM, hepatic, renal, and rheumatic) also significance associations between (skin rash in sun-exposed areas in hepatic diseases (p = 0.04), spooning of nails in renal disease (p = 0.06), Impaired night vision in cardiac and diabetic patients (p = 0.001), rheumatic diseases had more bone tenderness and diarrhea (p = 0.001) Conclusion:The most common nutritional deficiency manifestations among elderly were; thinning or loss of hair, corneal drying or clouding, bleeding gum, easy bruising, and bone tenderness. SGA based nutritional status of elderly was (35%) well-nourished, (49%) mild to moderate, and (16%) severe malnutrition.

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Section: Figure (1)supporting

confidence: 74%

Screening of Nutritional Deficiency Manifestations Among Egyptian Elderly: Cross-sectional study

al.¹

2022

The Egyptian Journal of Geriatrics and Gerontology

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“…Approximately one-third of HH patients present with skin hyperpigmentation, which can be generalized but is more commonly observed on exposed skin [2]. The hyperpigmentation can appear gray due to dermal iron accumulation (described as "slate-gray skin") or brown from increased melanin production [3,4]. Less frequently, the mucous membranes and conjunctiva may also be affected [3].…”

Section: Discussionmentioning

confidence: 99%

Ichthyosis Skin Changes in a Patient With Hereditary Hemochromatosis

Arora,

Nguyen,

Hudson

et al. 2024

Cureus

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Hereditary hemochromatosis (HH) is characterized by elevated iron absorption in the body, leading to iron accumulation with subsequent dysfunction and end-organ damage. While the progression of the disease can result in arthralgias, hepatomegaly, cardiomyopathies, and diabetes, over a third of HH patients present with cutaneous manifestations. We present the case of a 56-year-old male with HH who presented to dermatology with a rash and diffuse scaling. The patient exhibited brown plate-like scales clinically consistent with diffuse ichthyosis vulgaris. While ichthyosis has been seen in patients with idiopathic hemochromatosis, its association with HH is not well reported. Due to the high prevalence of cutaneous involvement in hereditary hemochromatosis, physicians should familiarize themselves with ichthyosis and the other dermatologic manifestations of this disease.

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“…Furthermore, other reviews of the symptomatology of hemochromatosis did not discuss pruritus as occurring. 9 – 12 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, other reviews of the symptomatology of hemochromatosis did not discuss pruritus as occurring. [9][10][11][12] Our case is a 70-year-old man presenting with generalized pruritus and evidence of hyperferritinemia. He had a single HFE mutation, which has not been shown to be a cause of hereditary hemochromatosis nor is it associated with hyperferritinemia in isolation.…”

Section: Discussionmentioning

confidence: 99%

Generalized pruritus as a symptom of hyperferritinemia: A case report and review of the literature

Osman

Haber

2022

SAGE Open Medical Case Reports

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Generalized pruritus can be the manifestation of many dermatologic and systemic diseases. However, it has been reported infrequently in the literature as a consequence of hyperferritinemia. We report the case of a 70-year-old male presenting to dermatology due to generalized pruritus in the absence of a rash, who was subsequently found to have a significantly elevated serum ferritin and transferrin saturation with otherwise normal iron studies. Hereditary hemochromatosis was ruled out on genetic testing; however, etiologies of secondary iron overload including alcohol use disorder and non-alcoholic fatty liver disease were present. The patient had minimal relief of his pruritus with topical corticosteroids, oral prednisone, and moisturizers. The only successful treatment was phlebotomy which resulted in complete resolution of his long-standing pruritus. We present the fifth case of generalized pruritus associated with hyperferritinemia, treated successfully with phlebotomy.

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Cutaneous Manifestations of Chronic Liver Disease

Cited by 7 publications

References 60 publications

Screening of Nutritional Deficiency Manifestations Among Egyptian Elderly: Cross-sectional study

Screening of Nutritional Deficiency Manifestations Among Egyptian Elderly: Cross-sectional study

Ichthyosis Skin Changes in a Patient With Hereditary Hemochromatosis

Generalized pruritus as a symptom of hyperferritinemia: A case report and review of the literature

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