Cutaneous Manifestations of Antiphospholipid Antibody Syndrome

Weinstein, Stuart; Piette, Warren W.

doi:10.1016/j.hoc.2007.10.011

Cited by 78 publications

(71 citation statements)

References 26 publications

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“…The exact cause of anetoderma is unknown. Possible explanations for loss of elastic tissue include defective elastin synthesis, uncontrolled production of elastolytic enzymes, loss of elastolytic enzyme inhibitors, elastophagocytosis, or degeneration of elastic fibers secondary to local ischemia induced by microthromboses in dermal vessels [5]. Diagnosis relays on histopathology findings which shows decrease in dermal thickness and normal collagen fibres and decrease in elastin fibres in upper dermis.…”

Section: Sirmentioning

confidence: 99%

Disseminated superficial porokeratosis and anetoderma developing after acute pancreatitis

Kolanuvada¹,

Chankramath²,

Ambika³

2012

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Sir,Disseminated superficial Porokeratosis is a heterogeneous group of disorders characterized by a distinct clinical finding of keratotic ridge with central groove that corresponds to cornoid lamella in histology. Anetoderma is characterised by localised loss of elastic tisssue resulting in herniation of subcutaneous tissue. We describe a rare association of disseminated superficial porokeratosis and anetoderma, which was developed after an episode of acute pancreatitis.A 56yr old male patient, farmer by occupation, was presented with multiple asymptomatic hyperpigmented annular lesions over the trunk since 8 months and multiple discrete yellowish sac like protrusions over trunk since 6 months. He gives h/o acute pancreatitis 10 months back for which he was treated conservatively. On examination there were multiple discrete annular hyperpigmented plaques of varying sizes with hyperkeratotic grooved borders over anterior and posterior aspects of the trunk and both the upper limbs and neck (Fig. 1). Multiple discrete yellowish sac like protrusions of sizes varying from 5mm to 10mm were seen over both the flanks and posterior aspect of the trunk. Button hole sign was positive (Fig. 2).Routine blood investigations and biochemical investigations were within normal limits. HIV and HBS Ag was negative. Histopathology of keratotic plaques showed foci of epidermal invagination filled with keratin and parakeratotic coronoid lamella ,dermis showed a mild to moderate infiltrate of lymphocytes and evidence of pigment incontinence which was consistent with porokeratosis (Fig. 3). Histopathology of sac like protrusions showed decreased elastic fibres in the papillary and reticular dermis. Staining with verhoeff-van Gieson was consistent with anetoderma (Fig. 4). With the above clinical and histopathological findings the diagnosis of disseminated superficial porokeratosis and anetoderma was confirmed. For larger lesions were treated with topical 5-flurouracil was given and smaller lesions with topical Tretinoin 0.05% cream. Significant improvement was seen within 3 months.

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Section: Sirmentioning

confidence: 99%

Disseminated superficial porokeratosis and anetoderma developing after acute pancreatitis

Kolanuvada¹,

Chankramath²,

Ambika³

2012

Our Dermatol Online

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“…Dermatological findings, although not pathognomonic, are important in the diagnosis of APS. Cutaneous necrosis, one of the recognized features in patients with APS, usually presents acutely with painful purpura 5,6,7 . Common sites involved are the extremities, cheek, trunk, forehead, and helices of ears 8 .…”

Section: To the Editormentioning

confidence: 99%

“…Common sites involved are the extremities, cheek, trunk, forehead, and helices of ears 8 . Other skin findings include livedo reticularis (most frequently associated with cutaneous APS manifestation), leg ulcers, pseudovasculitis, digital gangrene, and splinter hemorrhages 5,6 .…”

Section: To the Editormentioning

confidence: 99%

Antiphospholipid Syndrome with Cutaneous Necrotic Lesion of the Lower Limbs

Wan¹,

Zhao²,

Au-Yeung³

et al. 2011

J Rheumatol

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“…They can either be the consequence of repeated local infections or might be present before the onset of ulcer once leg ulcers are part of the clinical spectrum of antiphospholipid syndrome. 8,9 It might be important to recognize its role for the treatment of leg ulcers as these manifestations respond to the use of anticoagulant and anti-malarial drugs.…”

Section: Comunicationmentioning

confidence: 99%

Úlceras de pernas e anticorpos anticardiolipinas

Skare

2011

An. Bras. Dermatol.

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Prothrombotic phenomena are described in leg ulcers of different etiologies. This work attempts to verify the prevalence of anticardiolipin antibodies in such patients. For this purpose, 151 patients with leg ulcers and 150 control patients were studied and it was obtained clinical data and anticardiolipin antibodies titers. Anticardiolipin antibodies were detected in 7,2 % of the patients from the ulcer group against 1.3% of the patients in the control group (p=0.01) . However, clinical characteristics were not different in patients with and without anticardiopilin antibodies. Keywords: Antibodies, anticardiolipin; Diabetic foot; Venous insufficiency Resumo: Fenômenos pró-trombóticos são descritos em úlceras de perna de diferentes etiologias. Neste trabalho, procurou-se verificar a prevalência de anticorpos anticardiolipina nestes pacientes. Para isso, estudaram-se 151 pacientes com úlcera de pernas e 150 controles, sendo obtidos dados clínicos e títulos de anticorpos anticardiolipina. Os anticorpos anticardiolipina foram detectados em 7,2% do grupo úlcera e 1,3% do grupo controle (p=0.01), todavia, as características clínicas não foram diferentes nos pacientes com e sem anticorpos anticardiolipina.

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Cutaneous Manifestations of Antiphospholipid Antibody Syndrome

Cited by 78 publications

References 26 publications

Disseminated superficial porokeratosis and anetoderma developing after acute pancreatitis

Disseminated superficial porokeratosis and anetoderma developing after acute pancreatitis

Antiphospholipid Syndrome with Cutaneous Necrotic Lesion of the Lower Limbs

Úlceras de pernas e anticorpos anticardiolipinas

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