Cutaneous manifestations in patients with chronic kidney diseases on haemodialysis

Abstract

Background: Cutaneous and mucosal disorders are of the common problems in patients on long term haemodialysis. The aim of this study was to evaluate the frequency and nature of cutaneous lesions among patients with chronic kidney diseases who received maintenance haemodialysis.Methods: Eighty patients with chronic kidney diseases on haemodialysis were studied. All of the patients were fully examined for cutaneous, hair, nail and mucosal changes. Diagnostic measures such as scraping and biopsy of the lesions was carried out, where necessary.Results: The patients were 30 females and 50 males with a mean age of 47.6 years. The duration of haemodialysis was 36±11 months. All patients included in this study had at least one cutaneous manifestation attributable to CRF. The most prevalent findings were xerosis (66.2%) followed by pallor (57.5%), pruritus (51.25%), infections (33.75%), AV shunt dermatitis (16.25%), pigmentary changes (13.75%), purpura, ecchymoses (8.75%) and perforating disorders (2.5%). Hair changes were diffuse alopecia (16.25%), brittles, lustreless hair (3.75%) and sparse body hairs (1.25%). Oral changes were candidiasis (10%), angular cheilitis (3.75%), gingivitis (2.75%), fissured tongue (2.75%) and lichen planus (1.25%). Nail changes were leukonychia (10%), dystrophic nails (7.5%) onychomycosis (6.25%), subungual hyperkeratosis (5%) and half and half nails (1.25%).Conclusions: At least one cutaneous manifestation is found in all CRF patients. The etiology of CRF does not affect the cutaneous, hair or nail abnormalities. Factors such as diagnostic climate and early treatment influence some disorders such as xerosis, pruritus and infections.

Cutaneous Manifestations in Patients with Chronic Kidney Disease on Hemodialysis and its Correlation with Renal Function, Dialysis Cycle and Haemoglobin

“…4 These findings were not observed in our pa ents. There has also a report of skin changes in AV fistula that was not 3,4,5 observed in our study. Other miscellaneous skin findings were also observed in our pa ents, which may not be a ributed to CKD and dialysis.…”

“…It may be due to increased serum histamine levels because of allergic sensi za on to diverse dialyzer membrane components as well as impairing renal excre on of histamine. There is an abnormal pa ern of cutaneous innerva ons in CKD, which occurs due to slowly accumulated pruritogen, the 4,5 nature of which is uncertain. It may be secondary to anemia, xerosis, hypervitaminosis A, secondary hyperparathyroidism or increase levels of magnesium, calcium and phosphates 4 and serum histamine.…”

“…The prevalence of cutaneous manifesta on is high among dialysis pa ents. This occurs because of numerous factors such as uremia, metabolic disorders, dialysis and side effects of 5 immunosuppressive drugs.…”

Assessment of Skin Manifestations in End-Stage Renal Disease Patients Undergoing Hemodialysis in Shahid Beheshti Hospital of Abadan and Vali-e-Asr Hospital of Khorramshahr

“…This checklist was prepared by reviewing the relevant literature, books, and consultation with the nurses and physicians working at the hemodialysis wards. The questionnaire was distributed to 10 faculty members of Abadan Faculty of Nursing who were expert and qualified in this field Other diseases 17 (17) for evaluating the content and face validity. After updating the questionnaire according to the experts' opinions, in order to verify its reliability, a preliminary study was conducted on 20 patients.…”

Hemodiyaliz Hastalarında Cilt Sorunlarının Değerlendirilmesi

“…Hasta tanıtım ve anket formu: Yazarlar tarafından ilgili literatürler incelenerek oluşturulan hasta tanıtım formu; hastanın sosyodemografik özelliklerini içeren 8 soru, cilt yapısı ve kişisel hijyen alışkanlıklarını içeren 10 soru, SDBY ve HD süresi, hastanın diyete ve tedaviye uyumunu içeren 8 soru olmak üzere toplam 26 soru içermektedir (7)(8)(9)(10)(11)(12). Yaşanan cilt sorunlarının varlığı araştırmacılar tarafından fizik muayene ile, yaşanan semptomların şiddeti de hastalara sorularak subjektif olarak değerlendirilmiştir.…”