Cutaneous Manifestations in Patients Positive for Anti-Hepatitis C Virus Antibodies

BACKGROUND Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated. OBJECTIVESTo investigate the relationship between pemphigus and the hepatitis B and C virus infections. METHODSThis retrospective study included 62 patients with pemphigus and 50 healthy controls of matching ages and genders. The control group included relatives who accompanied the orthopedic patients to the hospital but had no history of systemic and/or autoimmune diseases. RESULTSThe group of patients with pemphigus was composed of 43 (69.3%) females and 19 (29.7%) males, and the mean age was 48.08 ± 15.38. The hepatitis C virus antibody was negative in all of the patients. Hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), or both, were studied in 44 of the 62 patients. Two (4.3%) of these patients were positive for HBsAg and found to have HBV infection. Fourteen of them were HBsAb positive. Two (4%) of the 50 control subjects showed hepatitis C virus antibody positivity, while only 1 (2%) patient with pemphigus displayed HBsAg positivity. There was no statistically significant difference between the two groups for hepatitis B and C virus infections. CONCLUSIONSThis study does not support an association between pemphigus and hepatitis B and/or C virus infections.

show abstract

“…13 In addition, the activation of B lymphocytes resulting from HCV residence on these cells has been seen as responsible for autoimmunity. 14 …”

Section: Discussionmentioning

confidence: 99%

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Demirci

Aydıngöz

Mansur

et al. 2014

An. Bras. Dermatol.

View full text Add to dashboard Cite

show abstract

“…To uncover possible publication bias, we assessed publication bias by using an inverted funnel plot in which the OR was plotted on a logarithmic scale on the vertical axis against the number of participants in each study on the horizontal axis (the standard error from each study). †References 12,15,[18][19][20]23,24,[33][34][35]57,62,72,43,44,[46][47][48][49][50][51]53,55,[57][58][59][60][61][62][63][66][67][68][69][70][71][72][73][74][75]15,18,21,22,[24][25][26][27]29,33,…”

Section: Discussionmentioning

confidence: 99%

“…¶References 20,21,35,36,43,44,46,53,58. #References 12,14,16,23,28,32,[38][39][40]44,47,[68][69][70][72][73][74][75] …”

Section: Comparison Of Prevalence Of Lp Exposure In Patients With Hcvmentioning

confidence: 99%

Hepatitis C Virus and Lichen Planus

Liu¹,

Songpo²,

Wen³

et al. 2009

Arch Dermatol

129

View full text Add to dashboard Cite

“…[ 16 ] (35%), and Soylu et al . [ 17 ] (48%), followed by pigmented purpuric eruption (5.2%), aphthous ulcer, lichen planus (3.9% each), and leukocytoclastic vasculitis (2.6%). [ 15 ] In our study also, pruritus was observed in 50% of patients with HCV infection with other common manifestations being ichthyosis/xerosis (57.1%), icterus (50%), clubbing (50%), and pallor (42.8%).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous manifestations in disorders of hepatobiliary system

Godara

Thappa

Pottakkatt

et al. 2017

Indian Dermatol Online J

View full text Add to dashboard Cite

Background:Hepatobiliary diseases are associated with various mucocutaneous changes that are directly and indirectly associated with these diseases. There is a dearth of studies from India dealing with cutaneous manifestations in liver disorders.Aim:This study was conducted to know the spectrum of cutaneous changes and their correlation with liver function tests in patients with disorders of hepatobiliary system.Methods:This was a descriptive study conducted among in patients and outpatients with primary hepatobiliary disorders at a tertiary care center in South India. Detailed history taking and examination was done. Visual analog score (VAS) and 5D itch score was employed to quantify pruritus. Correlation of liver function tests with pruritus and comparison of skin changes in the major disease groups was attempted.Results:A total of 303 patients were recruited. Hepatic mass/malignancy followed by nonalcoholic liver disease were the most common diagnoses. Icterus followed by pruritus were the most common cutaneous complaints. The mean VAS and 5D itch scores among the patients with pruritus were 4.7 ± 1.9 and 13.6 ± 4.9. The most common mucocutaneous findings observed were icterus (241 patients; 79.5%), ichthyosis/xerosis (172 patients; 56.7%), pallor (131 patients; 43.2%), excoriations (118 patients; 38.9%), hyperpigmented palmar creases (118 patients; 38.9%), clubbing (113 patients; 37.2%), and pedal edema (85 patients; 28%). There was statistically significant correlation between serum bilirubin levels and pruritus.Conclusion:The common mucocutaneous manifestations associated with primary hepatobiliary disorders were icterus, ichthyosis/xerosis, pallor, excoriations, hyperpigmented palmar creases, clubbing, and pedal edema.

show abstract

Cutaneous Manifestations in Patients Positive for Anti-Hepatitis C Virus Antibodies

Cited by 19 publications

References 34 publications

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Hepatitis C and hepatitis B virus infections in the etiopathogenesis of pemphigus

Hepatitis C Virus and Lichen Planus

Cutaneous manifestations in disorders of hepatobiliary system

Contact Info

Product

Resources

About