Cutaneous manifestations associated with melanoma

Vyas, Ritva; Selph, Jacqueline; Gerstenblith, Meg R.

doi:10.1053/j.seminoncol.2016.02.031

Cited by 13 publications

(11 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of one or multiple halo phenomena has been occasionally documented in melanoma patients and can occur around melanoma or nevi [49]. However, enough data are not available to estimate the significance of this occurrence.…”

Section: Sutton's Nevus and Halo Phenomenon In Melanoma Patientsmentioning

confidence: 99%

Melanoma and Vitiligo: In Good Company

Failla

Carbone

Fortes

et al. 2019

IJMS

View full text Add to dashboard Cite

Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo is an autoimmune disorder that leads to progressive destruction of skin melanocytes. However, vitiligo has been associated with cutaneous melanoma since the 1970s. Most of the antigens recognized by the immune system are expressed by both melanoma cells and normal melanocytes, explaining why the autoimmune response against melanocytes that led to vitiligo could be also present in melanoma patients. Leukoderma has been also observed as a side effect of melanoma immunotherapy and has always been associated with a favorable prognosis. In this review, we discuss several characteristics of the immune system responses shared by melanoma and vitiligo patients, as well as the significance of occurrence of leukoderma during immunotherapy, with special attention to check-point inhibitors.

show abstract

Section: Sutton's Nevus and Halo Phenomenon In Melanoma Patientsmentioning

confidence: 99%

Melanoma and Vitiligo: In Good Company

Failla

Carbone

Fortes

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…In the brain, the substantia nigra contains melanin, and it is present in many ocular tissues (including the iris, ciliary body, retinal pigment epithelium, choroid), inner ear, and skin [ 1 ]. In addition, the melanotic cells in melanoma can be densely pigmented [ 2 ]. Melanin is a macromolecule that is usually a mixture of two distinct polymers, namely black–brown eumelanin and red–yellow pheomelanin [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

et al. 2020

View full text Add to dashboard Cite

Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma. As melanin is present in many pigmented tissues in the human body, investigation of pigment binding is relevant in drug discovery and development. Conventionally, melanin binding assays have been performed using an equilibrium binding study followed by chemical analytics, such as LC/MS. This approach is laborious, relatively slow, and limited to facilities with high performance quantitation instrumentation. We present here a screening of melanin binding with label-free microscale thermophoresis (MST) that utilizes the natural autofluorescence of melanin. We determined equilibrium dissociation constants (Kd) of 11 model compounds with melanin nanoparticles. MST categorized the compounds into extreme (chloroquine, penicillin G), high (papaverine, levofloxacin, terazosin), intermediate (timolol, nadolol, quinidine, propranolol), and low melanin binders (atropine, methotrexate, diclofenac) and displayed good correlation with binding parameter values obtained with the conventional binding study and LC/MS analytics. Further, correlation was seen between predicted melanin binding in human retinal pigment epithelium and choroid (RPE-choroid) and Kd values obtained with MST. This method represents a useful and fast approach for classification of compounds regarding melanin binding. Thus, the method can be utilized in various fields, including drug discovery, pharmacokinetics, and toxicology.

show abstract

“…The diagnosis is of exclusion and should meet the criteria of Curth's postulates [ 5 ]. The best documented dermatoses in relation are dermatomyositis and pemphigus vulgaris [ 6 ]. Additionally, gyrate erythroderma [ 7 ], grover's disease [ 8 ] and Sweet's syndrome [ 9 ] have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Metastatic pulmonary melanoma complicated with erythroderma and recurrent sepsis

Wang

Zhou

et al. 2018

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

Erythroderma is occasionally associated with lung cancer. Here we report a 69-year-old male who has history of melanoma from 8 years ago presented with erythroderma associated with skin, soft tissue and pulmonary infection. CT chest showed a single enlarging right upper lobe lung nodule. Biopsy showed evidence of adenocarcinoma, and eventually proven to be metastatic melanoma. The patient improved after antibiotics and antifungal treatment. To our knowledge, this is the first case of melanoma metastasis presented as erythroderma as paraneoplastic syndrome.

show abstract

Cutaneous manifestations associated with melanoma

Cited by 13 publications

References 54 publications

Melanoma and Vitiligo: In Good Company

Melanoma and Vitiligo: In Good Company

Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs

Metastatic pulmonary melanoma complicated with erythroderma and recurrent sepsis

Contact Info

Product

Resources

About