Cutaneous Malignant Rhabdoid Tumor in the Palm of an Adult

Abstract

Malignant rhabdoid tumor is a rare tumor occurring mostly in the neonatal kidneys and central nervous system. Cutaneous malignant rhabdoid tumors are extremely rare in adults. The aim of the study was to report on the clinical, histologic, and immunophenotypic characteristics of this cutaneous malignant rhabdoid tumor which developed in an adult. A 27-year-old male complained of a right palm neoplasm that had been present for 6 months, which was initially diagnosed as an epithelioid sarcoma by biopsy. However, detailed investigation with immunohistochemistry enabled us to make a diagnosis of a rhabdoid tumor. The patient underwent radical abrasion, chemotherapy, and irradiation, and has survived for 1 year without relapse. Only 20 adult cases have been reported thus far in the English literature. We are reporting the 21st case, who remains disease-free at 12 months. Complete resection and local irradiation may increase survival, because there is no standard and reliable curative chemotherapeutic regimen.

Epithelioid Sarcoma Arising in a Long-Term Survivor of an Atypical Teratoid/Rhabdoid Tumor in a Patient With Rhabdoid Tumor Predisposition Syndrome

“…For instance, AT/RT is generally regarded as a brain tumor of infants and children, and ES is a soft tissue lesion of the trunk and extremities of individuals in at least their second decade. Rare exceptions exist: AT/RT and MRT have been described in the skin, 6–8 and intracranial ES has been reported. 9–11 The final diagnosis reported in each of these rare previously published cases resulted from difficult deliberation between similar entities and remains debatable; those lesions labeled as MRT or AT/RT may in fact represent ES, and vice versa.…”

Cutaneous amelanotic signet-ring cell malignant melanoma with interspersed myofibroblastic differentiation in a young cat

“…Malignant rhabdoid tumors are vimentin positive and have inconsistently been reported to express S100, NSE, and occasionally melan A. 6,10,11 Malignant triton tumors are described as vimentin and S100 positive. 20 Signet-ring cell melanomas in humans are commonly associated with metastatic or recurrent lesions.…”

“…5,7,15,22,23 Other tumors were excluded based on similar histologic appearance and overlapping expression patterns, for example, granular cell tumors (may resemble signet-ring cells, express S100 and frequently NSE, and, in rare cases, melan A), malignant triton tumors (may have similar mixed cell populations, and express vimentin and S100), extrarenal malignant rhabdoid tumors (may have similar mixed cell populations, express vimentin, and have inconsistently been reported to be S100, NSE, and melan A positive), pleomorphic rhabdomyosarcomas, plasmacytomas (may resemble signet-ring cells), and undifferentiated sarcomas (may also appear spindled and pleomorphic, and express vimentin). 6,10,11,15,16,20 Rhabdomyoblastic differentiation or lipid accumulations were ruled out by lack of cross striations using PTAH staining or by Sudan black B staining, respectively. Granular cell tumors, which are PAS positive and can also express vimentin and S100, were excluded by negative PAS staining (Fig.…”

“…4,5,7,15,22,23 Granular cell tumors, malignant triton tumors, extrarenal malignant rhabdoid tumors, pleomorphic rhabdomyosarcomas, undifferentiated sarcomas, and plasmacytomas can also exhibit similar morphology to round signet-ring cells (plasmacytoma, granular cell tumor), or spindle cells (undifferentiated sarcoma), or both cell types (malignant triton tumor, extrarenal malignant rhabdoid tumor, pleomorphic rhabdomyosarcoma). [4][5][6][7]10,11,15,16,20,22,23 644768V DIXXX10.1177/1040638716644768Signet-ring cell melanoma and myofibroblastic differentiationHirz, Herden…”