Cutaneous Malignant Melanoma Appearing during Photochemotherapy of Mycosis fungoides

Reseghetti, A.; Tribbia, G; Locati, Francesco; Naldi, Luigi; Marchesi, L.

doi:10.1159/000246790

Cited by 15 publications

(14 citation statements)

References 17 publications

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“…Of the 6 patients with melanoma, 3 had also been treated with PUVA and 2 with topical mechlorethamine. Other authors have also reported melanoma and MF in association, 5,6 and this has also been ascribed to the use of skin-directed treatments with carcinogenic potential. In addition to cutaneous malignancies there are reports of an increased incidence of internal malignancies for patients with CTCL.…”

Section: Discussionmentioning

confidence: 92%

Cutaneous malignant melanoma in association with mycosis fungoides

Evans¹,

Scarisbrick²,

Child³

et al. 2004

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 92%

Cutaneous malignant melanoma in association with mycosis fungoides

Evans¹,

Scarisbrick²,

Child³

et al. 2004

Journal of the American Academy of Dermatology

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“…In these cases, some of the same pathologic links as those put forward to explain the increased incidence of nonmelanoma skin cancers in MF have been postulated, including effects of therapies for MF. Melanoma has been reported in several MF patients treated with PUVA therapy 2,4,6 . While PUVA increases the risk of nonmelanoma skin cancers, its association with malignant melanoma has not been definitively demonstrated 11 .…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides associated with malignant melanoma and dysplastic nevus syndrome

2003

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There is an elevated prevalence of malignant melanoma in MF patients compared to the general US population (P < 0.00001) with a relative risk of 15.3 for observing malignant melanoma in MF patients (95% confidence interval 7.0-33.8). Possible pathologic links between the two diagnoses include effects of mycosis fungoides therapies, immunosuppression secondary to mycosis fungoides, and genetic alterations in the p16 tumor suppressor protein.

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“…This form of cancer is often fast‐growing and fatal. The literature contains a number of case reports on invasive cutaneous malignant melanomas 20 –28 but it has been difficult to determine whether these melanomas were induced by PUVA or were coincidental. Only one population‐based study has been published, 29 and for the first time it has shown an increased risk for malignant melanoma in patients treated with high cumulative doses of PUVA and, most important, after a latency period of at least 15 years.…”

Section: Discussionmentioning

confidence: 99%

PUVA and cancer risk: the Swedish follow-up study

et al. 1999

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There is concern about the long-term carcinogenic effects of psoralen and ultraviolet A radiation (PUVA) for treatment of skin disorders. Many authors have found an increased risk for cutaneous squamous cell carcinoma (SCC). Except in anecdotal reports, malignant melanoma had not been observed in patients treated with PUVA until recently. In the U.S.A., a 16-centre prospective study of 1380 patients showed for the first time that there might also be an increased risk for malignant melanoma in patients treated with high cumulative dosages of PUVA. We have therefore followed up the Swedish PUVA cohort until 1994. This cohort had previously been followed up until 1985. Information from 4799 Swedish patients (2343 men, 2456 women) who had received PUVA between 1974 and 1985 was linked to the compulsory Swedish Cancer Registry in order to identify individuals with cancer. The average follow-up period was 15.9 years for men and 16.2 for women. We did not find any increased risk for malignant melanoma in our total cohort of 4799 patients treated with PUVA or in a subcohort comprising 1867 patients followed for 15-21 years. For cutaneous SCC there was an increase in the risk: the relative risk was 5.6 (95% confidence interval, CI 4. 4-7.1) for men and 3.6 (95% CI 2.1-5.8) for women. Significant (P < 0.05) increases were also found in the incidence of respiratory cancer in men and women and of kidney cancer in women. In conclusion, we did not find any increased risk for malignant melanoma in our patients treated with high doses of PUVA and followed up for a long time. We confirm previous reports of an increase in the incidence of cutaneous SCC in patients treated with PUVA, and recommend that patients should be carefully selected for PUVA and rigorously followed up.

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Cutaneous Malignant Melanoma Appearing during Photochemotherapy of Mycosis fungoides

Cited by 15 publications

References 17 publications

Cutaneous malignant melanoma in association with mycosis fungoides

Cutaneous malignant melanoma in association with mycosis fungoides

Mycosis fungoides associated with malignant melanoma and dysplastic nevus syndrome

PUVA and cancer risk: the Swedish follow-up study

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