Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?

Chen, Tiffany; Morrison, Annie O.; Cockerell, Clay J.

doi:10.1111/cup.12975

Cited by 14 publications

(27 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Melanoma can mimic other skin lesions (e.g. NMSC 25 and SK 26–30 ), delaying proper diagnosis. Melanoma more frequently mimics benign skin lesions in pediatric populations; these mimics are often thicker and of higher stage 31 .…”

Section: Introductionmentioning

confidence: 99%

Clinical spectrum of cutaneous melanoma morphology

Klebanov

Gunasekera

Lin

et al. 2019

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical spectrum of cutaneous melanoma morphology

Klebanov

Gunasekera

Lin

et al. 2019

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

show abstract

“… 1 Its predilections are commonly found in sun-exposed areas, especially on the head and face. 3 Normally, a typical SK can be diagnosed clinically by well-demarcated and skin-colored to pigmented, papules, plaques or nodules, 2 with stuck-on appearance. 2 , 3 The hallmark of pathologic findings is hyperkeratosis, acanthosis, and papillomatosis.…”

Section: Discussionmentioning

confidence: 99%

“…Seborrheic keratoses (SK) are common benign skin tumors originating from epidermal keratinocytes and usually pigmented. 1 , 2 It is commonly identified in elderly, 3 which predilections are on the head and face. The classical skin lesions are characterized by well-demarcated and skin-colored to pigmented papules, plaques, or nodules with stuck-on appearance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Successful Defect Closure After Total Excision of Seborrheic Keratoses with Atypical Clinical Presentation Using Island Pedicle Flap in an Elderly Patient

Sutedja

Ahmed

Sutedja

et al. 2021

IMCRJ

View full text Add to dashboard Cite

Seborrheic keratoses (SK) are benign skin tumor characterized by well-demarcated and skin-colored to pigmented papules, plaques, or nodules with stuck-on appearance. Typical SKs are normally treated for cosmetic reasons. However, total excision and histopathological examination have to be considered in SK with unusual properties. The island pedicle flap (IPF) is a method of flap for defect closure, especially on the cheek. It has the capability to maintain the vascularization, thus it is also suitable in the elderly. We report a case of an SK with atypical clinical presentation in a 69-year-old female, with a solitary enlarging, hyperpigmented, verrucous, and bleeding tumor. The dermoscopic examination did not show characteristic features of SK. Total excision was performed due to its clinical properties. The histopathological examination revealed hyperkeratosis, acanthosis, hyperplasia, and papillomatosis, along with intercellular pseudo-horn cyst which confirmed the diagnosis of SK. The patient underwent total excision of the skin lesion which left a primary defect. We performed IPF procedure to reconstruct the defect after total excision of the skin lesion. After a year of follow-up, no meaningful complication was detected. The final result of the procedure was satisfying due to its ability to restore the natural contour and texture match by utilizing cheek laxity, without interfering the nasolabial fold. In conclusion, IPF is an appropriate method for defect closure in an elderly patient after facial total tumor excision.

show abstract

“…In a study by Cascajo et al, BCC were documented in 43 out of 54 malignancies associated with SK. A recent large study showed 136 malignancies were found in 4361 SK cases; the most common malignancy was in situ or invasive squamous cell carcinoma and the second most common malignancy was BCC (24.3%, 33/136). In our previous study, about 0.9% (17/1904 from 2001 to 2010) of SK had bowenoid transformation .…”

Section: Discussionmentioning

confidence: 99%

Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation?

Flordelis

Shen

2019

J Cutan Pathol

View full text Add to dashboard Cite

Background: Basaloid tumors arising from seborrheic keratosis (SK) that resembled basal cell carcinoma (BCC) were infrequently observed in our patients. They also exhibited morphologic features similar to those of trichoblastoma or basaloid follicular hamartoma. Methods:We retrospectively collected cases of SK with basaloid tumors from 2001 to 2017. Ten cases of BCC, five of nevus sebaceus with trichoblastoma, five of trichoblastoma, and five of trichoepithelioma were included as controls. Tumorassociated antigens Bcl-2, CD10, PHLDA1, and CK20 were tested. Antigenic markers CD34 and CD10 were used to analyze peritumoral stroma features and Ki-67 and pHH3 to measure the mitotic activity.Results: Ten cases of SK with basaloid tumors were found and all located in non-sunexposed areas, including five men and five women, with a mean age of 61 years. A distinct PHLDA1 staining was not observed. The staining patterns of basaloid tumor lobules associated with SK were similar to the benign control group. Bcl-2 staining in the tumor lobules was mostly negative. Peritumoral CD10 stain and CK20-positive Merkel cells in the lobules were observed and the mitotic counts were low.Conclusion: Basaloid tumors arising from SK are not always BCC. They were all benign follicular hamartomatous proliferation in this case series. K E Y W O R D S basal cell carcinoma, basaloid tumor, follicular induction, immunohistochemistry, seborrheic keratosis

show abstract

Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?

Abstract: SK may mimic cancer even in clinically unsuspicious cases.

Cited by 14 publications

References 10 publications

Clinical spectrum of cutaneous melanoma morphology

Clinical spectrum of cutaneous melanoma morphology

A Successful Defect Closure After Total Excision of Seborrheic Keratoses with Atypical Clinical Presentation Using Island Pedicle Flap in an Elderly Patient

Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation?

Contact Info

Product

Resources

About