1992
DOI: 10.1001/archderm.128.3.377
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Cutaneous macroglobulinosis. A case report with unique ultrastructural findings

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Cited by 17 publications
(14 citation statements)
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“…The microscopic differential diagnosis of cutaneous macroglobulinosis includes conditions characterized by the deposition of eosinophilic, amorphous material in the dermis. 6 In addition, as shown by the pathologic findings in this and prior reports, monoclonal cryoglobulin vasculopathy should also be considered. 4 Lipoid proteinosis is a rare autosomal-recessive deposition disorder due to mutations in the extracellular matrix protein 1 (ECM1) gene that manifests clinically with facial papules, nodules and pitted scars and verrucous lesions favoring the elbows, knees and hands.…”
Section: Discussionmentioning
confidence: 69%
“…The microscopic differential diagnosis of cutaneous macroglobulinosis includes conditions characterized by the deposition of eosinophilic, amorphous material in the dermis. 6 In addition, as shown by the pathologic findings in this and prior reports, monoclonal cryoglobulin vasculopathy should also be considered. 4 Lipoid proteinosis is a rare autosomal-recessive deposition disorder due to mutations in the extracellular matrix protein 1 (ECM1) gene that manifests clinically with facial papules, nodules and pitted scars and verrucous lesions favoring the elbows, knees and hands.…”
Section: Discussionmentioning
confidence: 69%
“…Direct immunofluorescence shows strong stain for immunoglobulin M. Ultrastructurally, the deposits are composed of amorphous or granular and sometimes filamentous material without periodicity of amyloid. 19 In summary, we present a rare case of primary localized cutaneous nodular amyloidosis with a unique histological picture of amyloid elastosis, a rare disease described only in patients with primary systemic amyloidosis.…”
Section: Discussionmentioning
confidence: 88%
“…A variety of skin manifestations have been observed in association with IgM antibodies reacting to the BMZ (summarized in Table 1). IgM deposits have been demonstrated in the pruritic papular skin lesions in rare cases of Waldenstrom's macroglobulinaemia (10)(11)(12)(13)(14). This eruption is called an IgM storage papule or cutaneous macroglobulinosis, which is histologically characterized by a massive dermal collection of amorphous, eosinophilic and fissured material.…”
Section: Discussionmentioning
confidence: 99%