Cutaneous lipomatous neurofibroma: characterization and frequency

Val-Bernal, J. Fernando; González‐Vela, M. Carmen

doi:10.1111/j.0303-6987.2005.00311.x

Cited by 40 publications

(56 citation statements)

References 20 publications

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“…In the skin, lipomatous metaplasia is very uncommon. It is discussed to play a role in the pathology of the rare lipomatous neurofibromas [6], but a diffuse lipomatous metaplasia of the dermis as seen in our patient has, at least to our knowledge, not been described so far.…”

Section: Discussionmentioning

confidence: 81%

Lipomatous Metaplasia after Severe and Chronic Cutaneous Inflammation

Eyerich¹,

Traidl‐Hoffmann²,

Albert³

et al. 2008

Dermatology

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A 69-year-old woman with a history of acute generalized exanthematic pustulosis (AGEP) caused by metamizole is described. Furthermore, she had suffered from an untreated psoriasis since the age of 20. After an adequate therapy of both psoriasis and AGEP, yellow-brownish, static, coalescing, lucent nodules on the thighs and upper arms became apparent. Histology of skin biopsies revealed a prominent band of mature adipocytes in the dermis. We diagnosed a lipomatous metaplasia of the dermis and hypothesize that this metaplasia occurred as a consequence of the severe and chronic inflammation of the skin.

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Section: Discussionmentioning

confidence: 81%

Lipomatous Metaplasia after Severe and Chronic Cutaneous Inflammation

Eyerich¹,

Traidl‐Hoffmann²,

Albert³

et al. 2008

Dermatology

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“…Several histologic variants have been recognized over time, including classic, plexiform, cellular, epithelioid, myxoid, hyalinized, pacinian, pigmented, and granular cell variant [3][4][5]. In addition, some cases of neurofibroma with epithelial, rhabdomyomatous and lipomatous differentiation, or dendritic cells with pseudorosette formation have also been described [1,[6][7][8]. Although neurofibroma may present a wide morphological spectrum, only the plexiform neurofibroma, a tumor mass grossly consisting of tortuous expanded nerved branches, is virtually pathognomonic of NF1 [1,2].…”

Section: Introductionmentioning

confidence: 99%

Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases

et al. 2009

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Multinucleated floret-like giant cells (MNFGCs), similar to those commonly observed in pleomorphic lipoma and giant cell fibroblastoma, have been occasionally reported in gynecomastia and neurofibromas from patients affected by neurofibromatosis type 1 (NF1). Accordingly, it has been suggested that their detection, especially in an otherwise typical neurofibroma, could be a morphological clue to diagnosis of NF1. The aim of the present study was the identification of MNFGCs in a large series (94 cases) of sporadic and NF1-associated neurofibromas, to assess if their presence may indeed be a morphological marker of NF1. Numerous MNFGCs, namely, those that were easily apparent at low magnification (x50 and x100), were identified only in 5.3% of cases. In 18.1% of cases, a low number of these cells could be observed but only after a careful search, especially at higher magnification (x200 and x400). Immunohistochemically, all MNFGCs were stained with vimentin and CD34, but not with S-100 protein. Interestingly, there was no statistically significant correlation between MNFGCs (presence or absence) and NF1 (p = 0.73), gender (p = 0.59), age (p = 0.43), and site of tumor (cutaneous vs deep-seated soft tissue; p = 0.27). Our clinicopathologic findings suggest that MNFGCs in an otherwise typical neurofibroma are not a reliable marker of NF1, likely representing a morphological reactive change of the indigenous dermal or endoneurial fibroblasts or dendritic cells in response to unknown microenvironmental stimuli.

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“…We therefore prefer to refer to this phenomenon as lipomatous change. Other neuroectodermal tumors that may contain adipocytes include cutaneous melanocytic nevi [7], schwannoma [8], neurofibroma [9], perineurioma [10], meningioma [11] and adrenal adenoma [12]. In most cases as well as in the current case, the cells retain at least some of the characteristics of their original lineage, which would argue against true metaplasia.…”

Section: Discussionmentioning

confidence: 93%

Lipomatous Change in Uveal Melanoma: Histopathological, Immunohistochemical and Cytogenetic Analysis

et al. 2015

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Purpose: The aim of this study was to describe a case of lipomatous change in uveal melanoma. Procedures: The patient presented with a 2-year history of blurry vision. A full examination of the right eye revealed a dome-shaped pigmented subretinal mass in the choroid with a thickness of 9 mm and a diameter of 15 mm. The eye was enucleated and prepared for histopathologic, genetic and molecular investigation. Results: Histopathology revealed a small circumscribed area consisting of mature adipocytic appearing cells with abundant clear cytoplasm and small peripheral flattened nuclei within a spindle-cell melanoma of the uvea. The cytoplasm of the adipocytic cells stained negative for periodic acid-Schiff and Alcian blue and positive for Melan-A, HMB-45 and tyrosinase, confirming melanocytic lineage. Fluorescence in situ hybridization analysis confirmed trisomy of chromosome 6p22 and disomy of chromosome 3p13 in the nuclei of both the tumor spindle type B cells and in the nuclei of lipomatous tumor cells. Conclusions: Lipomatous change can be added to the many histopathologic faces of uveal melanoma. To our knowledge, this is the first report of lipomatous change in uveal melanoma performed with cytogenetic investigations.

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Cutaneous lipomatous neurofibroma: characterization and frequency

Cited by 40 publications

References 20 publications

Lipomatous Metaplasia after Severe and Chronic Cutaneous Inflammation

Lipomatous Metaplasia after Severe and Chronic Cutaneous Inflammation

Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases

Lipomatous Change in Uveal Melanoma: Histopathological, Immunohistochemical and Cytogenetic Analysis

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