Cutaneous leukocytoclastic vasculitis revealing multifocal tuberculosis

Abstract

Cutaneous leukocytoclastic vasculitis (CLV) is an inflammatory vascular disorder rarely reported to be associated with tuberculosis. The following report describes the case of a young man with multifocal tuberculosis revealed by CLV. Diagnosis was confirmed by the presence of tuberculoid granuloma with caseous necrosis on pleural and perianal biopsy, and a rapid improvement in anti-tuberculous quadritherapy. Although rarely seen, Mycobacterium tuberculosis should be considered as a potential cause of CLV.

A Case of Tuberculosis-related Leukocytoclastic Vasculitis Presenting With Peripheral Neuropathy

“…Neuropathy as a result of allergic vasculitis is extremely rare in the case of tuberculosis [9,10]. Cutaneous leukocytoclastic vasculitis has been reported previously to accompany tuberculosis including pulmonary tuberculosis, tubercular lymphadenitis, and multifocal tuberculosis [9,11]. The exact mechanism of cutaneous leukocytoclastic vasculitis is still not known.…”

The Unusual Occurrence of Leukocytoclastic Vasculitis in Pulmonary Tuberculosis-Case Report

“…It occurs due to deposition of immune complexes in the dermal vessel wall; secondary to infections, malignancies, collagen vascular disorders, or exposure to drugs. Despite tuberculosis being so prevalent in India, leukocytoclastic vasculitis secondary to this infection is very rare, with < 20 cases reported globally [1]. Unlike cutaneous tuberculosis, this condition does not show the presence of the bacilli in the dermal vessel walls [1].…”

“…Despite tuberculosis being so prevalent in India, leukocytoclastic vasculitis secondary to this infection is very rare, with < 20 cases reported globally [1]. Unlike cutaneous tuberculosis, this condition does not show the presence of the bacilli in the dermal vessel walls [1]. The various proposed mechanisms of pathogenesis are: Direct invasion of the vessel wall, immune complex deposition in the vessel wall, hypersensitivity reaction following the intravascular release of the bacilli, or rifampicin-dependent antibody formation and then immune complex formation [2].…”

Fatal gastrointestinal bleeding due to IgA vasculitis complicated with tuberculous lymphadenitis: A case report and literature review

“…We searched for relevant English and Japanese articles in PubMed using the following keywords: IgA vasculitis, Henoch‐Schönlein purpura or leukocytoclastic vasculitis, and tuberculosis. Twenty‐six cases considered as IgAV met the classification criteria set by the ACR or the EULAR/PRINT/PRES 9‐29 ; these consisted of 14 cases before the treatment of tuberculosis (pretreatment group) and 12 cases after the treatment of tuberculosis (post‐treatment group) (Tables 1 and 2). The overall median age of patients was 37 years, and 19 (73.1%) of them were male.…”