Cutaneous Leiomyosarcoma

Ikari, Yuko; Tokuhashi, Itaru; Haramoto, Izumi; Morita, Makoto; Chiba, Toshiko; Shimoda, Nagayoshi; Mizoguchi, Masahiro; Seki, Kenjiro; Tadokoro, Mamoru; Ohya, Kazumitsu

doi:10.1111/j.1346-8138.1992.tb03188.x

Cited by 9 publications

(8 citation statements)

References 3 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, these tumours have been poorly characterized in terms of both pathological features and clinical outcome. To date, LMS of the skin has been analysed only in a few studies of any significant size 1–7 and in numerous smaller investigations 8–26 . In most of these studies, the specific pathological features and clinical outcome of cutaneous LMS are difficult to establish because true cutaneous LMS have not been analysed separately from subcutaneous LMS.…”

Section: Introductionmentioning

confidence: 99%

“…To date, LMS of the skin has been analysed only in a few studies of any significant size [1][2][3][4][5][6][7] and in numerous smaller investigations. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] In most of these studies, the specific pathological features and clinical outcome of cutaneous LMS are difficult to establish because true cutaneous LMS have not been analysed separately from subcutaneous LMS. Diagnostic criteria have not been precisely defined so far, and available recommendations tend to remain vague and, not infrequently, difficult to apply.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases

et al. 2009

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases

et al. 2009

View full text Add to dashboard Cite

show abstract

“…3 When occurring on areas prone to acne, such as the face, neck, and upper trunk, they are believed to result from damage to the pilosebaceous unit. 2 This explanation is not valid for their location in the nail apparatus, however.…”

Section: Discussionmentioning

confidence: 99%

“…Histoplasmosis was ®rst described in patients with acquired immunode®ciency syndrome (AIDS) in 1983. 2,3 In one series of AIDS patients, 4 the most common manifestations of disseminated histoplasmosis included fever, weight loss, splenomegaly, and hematologic abnormalities. Disseminated histoplasmosis was the initial presentation of human immunode®ciency virus (HIV) infection in 75% of patients in that series.…”

Section: Discussionmentioning

confidence: 99%

“…1 Even though epidermoid cysts are among the most common benign tumors of the skin, their location in the nail apparatus is infrequent. 2 In the skin, they are slow growing, round, ®rm, intradermal or subcutaneous tumors that develop from the epithelium of the follicular infundibulum. 3 When occurring on areas prone to acne, such as the face, neck, and upper trunk, they are believed to result from damage to the pilosebaceous unit.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Disseminated histoplasmosis presenting as pyoderma gangrenosum‐like lesions in a patient with acquired immunodeficiency syndrome

Laochumroonvorapong

DiCostanzo

et al. 2001

Int J Dermatology

View full text Add to dashboard Cite

A 33-year-old Hispanic woman with newly diagnosed human immunodeficiency virus (HIV) infection, a CD4 T-lymphocyte count of 2, viral load of 730,000 copies/mL, candidal esophagitis, seizure disorder, a history of bacterial pneumonia, and recent weight loss was admitted with tonic clonic seizure. On admission, her vital signs were: pulse of 88, respiration rate of 18, temperature of 37.7 degrees C, and blood pressure of 126/76. Her only medication was phenytoin. On examination, the patient was found to have multiple umbilicated papules on her face, as well as painful, erythematous, large, punched-out ulcers on the nose, face, trunk, and extremities of 3 months' duration (Fig. 1). The borders of the ulcers were irregular, raised, boggy, and undermined, while the base contained hemorrhagic exudate partially covered with necrotic eschar. The largest ulcer on the left mandible was 4 cm in diameter. The oral cavity was clear. Because of her subtherapeutic phenytoin level, the medication dose was adjusted, and she was empirically treated with Unasyn for presumptive bacterial infection. Chest radiograph and head computed tomography (CT) scan were within normal limits. Sputum for acid-fast bacilli (AFB) smear was negative. Serologic studies, including Histoplasma antibodies, toxoplasmosis immunoglobulin M (IgM), rapid plasma reagin (RPR), hepatitis C virus (HCV), and hepatitis B virus (HBV) antibodies were all negative. Examination of the cerebrospinal fluid was within normal limits without the presence of cryptococcal antigen. Blood and cerebrospinal cultures for bacteria, mycobacteria, and fungi were all negative. Viral culture from one of the lesions was also negative. The analysis of her complete blood count showed: white blood count, 2300/microl; hemoglobin, 8.5 g/dL; hematocrit, 25.7%; and platelets, 114,000/microl. Two days after admission, the dermatology service was asked to evaluate the patient. Although the umbilicated papules on the patient's face resembled lesions of molluscum contagiosum, other infectious processes considered in the differential diagnosis included histoplasmosis, cryptococcosis, and Penicillium marnefei. In addition, the morphology of the ulcers, particularly that on the left mandible, resembled lesions of pyoderma gangrenosum. A skin biopsy was performed on an ulcer on the chest. Histopathologic examination revealed granulomatous dermatitis with multiple budding yeast forms, predominantly within histiocytes, with few organisms residing extracellularly. Methenamine silver stain confirmed the presence of 2-4 microm fungal spores suggestive of Histoplasma capsulatum (Fig. 2). Because of the patient's deteriorating condition, intravenous amphotericin B was initiated after tissue culture was obtained. Within the first week of treatment, the skin lesions started to resolve. Histoplasma capsulatum was later isolated by culture, confirming the diagnosis. The patient was continued on amphotericin B for a total of 10 weeks, and was started on lamivudine, stavudine, and nelfinavir for her HIV infectio...

show abstract

Tumours of Soft Tissue and Bone, and Other Mesenchymal Tumours

Eyden

Banerjee

2013

The Ultrastructure of Human Tumours

View full text Add to dashboard Cite

Cutaneous Leiomyosarcoma

Cited by 9 publications

References 3 publications

Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases

Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases

Disseminated histoplasmosis presenting as pyoderma gangrenosum‐like lesions in a patient with acquired immunodeficiency syndrome

Tumours of Soft Tissue and Bone, and Other Mesenchymal Tumours

Contact Info

Product

Resources

About