Cutaneous involvement in the Deep Mycoses: A Review. Part II—Systemic Mycoses

Carrasco-Zuber, Juan Eduardo; Navarrete-Dechent, C.; Bonifáz, Alexandro; Fich, Félix; Vial-Letelier, Verónica; Berroeta-Mauriziano, Daniela

doi:10.1016/j.adengl.2016.05.027

Cited by 10 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…duboisii even if in this case the travel history could exclude this last etiology. 3,18,19 The accuracy of microscopic examination depends on the quality of the specimen and the experience of the pathologist. A consistent morphology showing typical round-or ovalshaped cells with connecting tubular projections seen at cytology and/or histology might be suggestive of Lacazia identification, particularly considering their remarkable uniformity in size and the tendency to produce chains of cells.…”

Section: Discussionmentioning

confidence: 99%

“…These characteristics allow to differentiate them from other subcutaneous mycoses, such as paraccocidiodomycosis (Paracoccidioides brasiliensis rarely has thin wall 3 or 4-cell chains), blastomycosis (B. dermatitidis presents a thick wall and usually single blastoconidia, smaller than the parent cell), and African histoplasmosis (cells are uniform in size, with relatively thick walls but presenting solitary, large blastoconidia attached to the parent cell by narrow necks). 18,19 In support to microscopical approaches, molecular tools using DNA characterization allow to obtain species identification. 15 An additional benefit of PCR and sequencing methods is the possibility to investigate paraffined and fixed material any time fungal elements are microscopically described by the pathologist.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela

Beltrame

Danesi

Farina

et al. 2017

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by , an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion. Blastomycosis and cryptococcosis were hypothesized based on microscopic morphology of yeast-like bodies found in three consecutive biopsies, although fungal cultures were always negative. In 2016, exfoliative cytology and a biopsy specimen examination showed round yeast-like organisms (6-12 μm), isolated or in a chain, connected by short tubular projections fulfilling the morphologic diagnostic criteria of spp. The microscopic diagnosis was confirmed by molecular identification.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela

Beltrame

Danesi

Farina

et al. 2017

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…La enfermedad tiene curso crónico, es limitada a la piel y al tejido celular subcutáneo, rara vez alcanza diseminación linfática y puede llegar a comprometer las estructuras óseas (31,32) . Clínicamente, inicia como pápula o nódulo eritematoso, pequeño, unilateral, pruriginoso, doloroso o asintomático, que se extiende lentamente a la piel adyacente, pudiendo ir desde pocos milímetros hasta centímetros.…”

Section: Cromoblastomicosisunclassified

Síndrome linfocutáneo de causa infecciosa: revisión narrativa y enfoque diagnóstico

Soto¹,

Reyes²,

Alvarez³

et al. 2020

rev. asoc. colomb. dermatol. cir. dematol.

View full text Add to dashboard Cite

Introducción: el síndrome linfocutáneo es una forma clínica muy característica de linfangitis, que se presenta con nódulos inflamatorios subcutáneos que siguen un trayecto. Se han descrito múltiples patologías infecciosas que podrían tener esta presentación clínica y su enfoque diagnóstico es clave para un tratamiento acertado. Métodos: se realizó una búsqueda en PubMed MEDLINE y, posteriormente, una revisión narrativa describiendo las diferentes etiologías infecciosas del síndrome linfocutáneo. Resultados: el síndrome linfocutáneo puede tener múltiples causas, dentro de las cuales se encuentran infecciones micóticas, bacterianas, por micobacterias típicas o atípicas, y parásitos, siendo Sporothrix schenckii, Nocardia brasiliensis, Mycobacterium marinum y Leishmania sp. los agentes más frecuentemente asociados. Para determinar su etiología, es necesario considerar aspectos en la anamnesis (procedencia, ocupación, tiempo de evolución, antecedente de trauma), semiología de las lesiones, sintomatología asociada y, en muchos casos, confirmación diagnóstica con biopsias de piel, cultivo o tinción de Gram, u otros. Su tratamiento debe ser dirigido y, generalmente, debido al compromiso de trayectos linfáticos, se extiende por más tiempo respecto a las infecciones localizadas. Conclusiones: cuando nos enfrentamos a un paciente con hallazgos sugestivos de síndrome linfocutáneo, debemos considerar múltiples etiologías infecciosas. Con el fin de hacer más sencillo el enfoque diagnóstico, proponemos clasificar los agentes causales en 4 grandes grupos: infecciones micóticas, bacterianas, por micobacterias y parasitarias.

show abstract

“…(b) Subcutaneous fungal infections include sporotrichosis, chromoblastomycosis, mycetoma, phaeohyphomycosis, hyalohyphomycosis and lacaziosis . (c) Paracoccidioidomycosis, coccidioidomycosis, histoplasmosis, mucormycosis and cryptococcosis are common systemic fungal infections . Subcutaneous and systemic mycoses occur mainly in immunosuppressed patients .…”

Section: Introductionmentioning

confidence: 99%

“…Subcutaneous and systemic mycoses occur mainly in immunosuppressed patients . Systemic fungal infections are linked to significant morbidity and mortality . In addition, fungal spores, for example, Aspergillus spores, are important allergenic agents and can cause persistent allergic inflammation of the airways …”

Section: Introductionmentioning

confidence: 99%

The complex role of mast cells in fungal infections

Jiao

Luo

Zhao

et al. 2019

Experimental Dermatology

View full text Add to dashboard Cite

In addition to their critical role in allergic disorders, mast cells (MCs) are well recognized for their protective effector functions during bacteria and parasite infections. This review describes recent advancements of our understanding of the complex role of MCs in fungal infections. Specifically, we outline key features of the contribution of MCs to infections with six fungal pathogens, namely Sporothrix, Paracoccidioides, Aspergillus, Malassezia, Candida and Dermatophytes. Evidence from studies of these pathogens suggests that MCs can function as positive regulators that detect and contain fungi at the site of infection. However, it appears that the inflammation induced by MCs following fungal infections may not always and only be beneficial to the host. MC responses during fungal infections may primarily benefit the pathogen by facilitating its spreading and contributing to a greater severity of fungal infections. This review also highlights key drivers of MCs activation and effector mechanisms that have been identified for the multidimensional function of MCs in fungal diseases and in allergic diseases combined with fungal infection.

show abstract

Cutaneous involvement in the Deep Mycoses: A Review. Part II—Systemic Mycoses

Cited by 10 publications

References 26 publications

Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela

Case Report: Molecular Confirmation of Lobomycosis in an Italian Traveler Acquired in the Amazon Region of Venezuela

Síndrome linfocutáneo de causa infecciosa: revisión narrativa y enfoque diagnóstico

The complex role of mast cells in fungal infections

Contact Info

Product

Resources

About