Cutaneous Infiltration due to Waldenström Macroglobulinemia

Oscoz-Jaime, S.; Agulló-Pérez, A.D.; Llanos-Chavarri, C.; Yanguas-Bayona, J.I.

doi:10.1016/j.adengl.2017.11.015

Cited by 3 publications

(8 citation statements)

References 6 publications

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“…In this last patient, an initial diagnosis of marginal zone lymphoma (MZL) had been made, and secondarily corrected to WM after the haematological diagnosis. In 6 cases, the WM preceded the occurrence of cutaneous lesions with a median delay of 3.5 years (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). In these cases, cutaneous progression was isolated at occurrence of skin lesions in 3 patients, while in 3 other cases there was an associated haematological progression.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast with nontransformed WM, transformed WM is associated with extranodal involvement in more than 90% of cases (9), including the skin in 12% (4). Overall, only a few case reports and a few small case series of WM involving the skin have been published (6,7,(10)(11)(12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

“…Sarah STIEN 1 , Eric DUROT 2 , Anne DURLACH 3 , Marie BEYLOT-BARRY 4 , Henri ADAMSKI 5 , Helmut BELTRAMINELLI 6 , Gérôme BOHELAY 7 , Agnès CARLOTTI 8 , Olivier CARPENTIER 9 , Pascale CORNILLET 10 , Romain DUBOIS 11 , Nathalie FRANCK 12 , Bérengère HUSSON 1 , Liliane LAROCHE 7 , Eve MAUBEC 7 , Christian LE CLECH 13 , Laurent MACHET 14 , Nicolas ORTONNE 15 , Caroline RAM-WOLFF 16 , Béatrice VERGIER 17 and Florent GRANGE 1…”

Section: Cutaneous Involvement In Waldenström's Macroglobulinaemiamentioning

confidence: 99%

“…Cutaneous macroglobulinosis has been widely described (3). In contrast, only isolated case reports and small series of lymphomatous skin involvement associated with WM have been reported to date (5)(6)(7). The aim of this multicentre retrospective study was to describe clinical, biological and histological features, therapeutic approaches, clinical outcome and prognosis of cutaneous involvement in WM.…”

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confidence: 99%

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Cutaneous Involvement in Waldenström’s Macroglobulinaemia

Stien

Durot²,

Durlach³

et al. 2020

Acta Derm Venereol

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Skin involvement in Waldenström's macroglobulinaemia is poorly described, and diagnosis of this disorder may be difficult. Many differential diagnoses are possible (other lymphomas, primary cutaneous lymphoma, etc.). Describing 2 aspects of Waldenström's macroglobulinaemia (infiltration by lymphoplasmacytic tumour cells or histological transformation into diffuse large B-cell lymphoma) allows the identification of clinical, histological and immunohistochemical diagnostic aids. Detection of the MYD88 L265P mutation is of interest. This study identified a characteristic clinical picture in non-transformed cases, and was able to distinguish between transformed and non-transformed cases by their severity and poor prognosis. Cutaneous involvement in Waldenström's macroglobulinaemia (WM) has been poorly characterized. To describe this involvement, a retrospective study of 19 patients with WM and cutaneous involvement of tumour B cells was performed. Twelve patients (group 1) had lymphoplasmacytic, non-transformed cutaneous proliferation, while in 7 cases (group 2) cutaneous involvement corresponded to histological transformation. In group 1, skin involvement was inaugural in 6 cases. The lesions were infiltrated plaques (83%), papules (25%) and tumours (42%). Four patients had a similar clinical picture (purplish, bilateral and symmetrical infiltration on the face). MYD88 L265P mutation was detected in the skin biopsy in all 6 cases tested. The 3-year specific survival rate was 88%. In group 2, cutaneous transformation occurred during the followup of the WM (71%). Lesions presented as ulcerated tumours (86%) of the trunk (57%) and lower limbs (57%). The 3-year specific survival rate was 22%. Skin involvement in WM has distinctive characteristics (e.g. clinical, histological, immunohistochemical, MYD88 L265P mutation).

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cutaneous Involvement In Waldenström's Macroglobulinaemiamentioning

confidence: 99%

mentioning

confidence: 99%

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Cutaneous Involvement in Waldenström’s Macroglobulinaemia

Stien

Durot²,

Durlach³

et al. 2020

Acta Derm Venereol

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show abstract

“…Infiltration of clonal lymphoplasmacytic cells in the skin, as seen on our patient’s biopsy, results in erythematous plaques of variable size, most often on the face/trunk. 1 , 2 Primary cutaneous marginal zone lymphoma – Incorrect. While primary cutaneous marginal zone lymphoma can have a similar clinical presentation, histopathology would demonstrate dermal infiltrates of mature B-cells/plasma cells which can be nodular or diffuse with varying degrees of plasmacytoid differentiation (CD123 expected to be positive).…”

Section: Historymentioning

confidence: 99%